Results 261 to 270 of about 620,051 (323)

Pathological characteristics of SARS-CoV-2 variants and immune responses induced in a COVID-19 macaque model. [PDF]

Commun Biol
Urano E, Okamura T, Higuchi M, Furukawa M, Ueda K, Nagata S, Kamada H, Yasutomi Y.   +7 more
europepmc   +1 more source

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Glutamine antagonist DON attenuates chikungunya virus-induced myositis by suppressing inflammatory activation in a murine model. [PDF]

Emerg Microbes Infect
Zhang X, Zhang Y, Huang J, Ma Z, Yan H, Zhong M, Yang J, Hu F, Zeng M, Lu M, Yan H, Zhang E.   +11 more
europepmc   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Testing menstrual blood for human papillomavirus during cervical cancer screening in China: cross sectional population based study. [PDF]

BMJ
Tian X, Cao C, Wang L, Zhang J, Chen Y, Tian R, Zhou B, Sun L, Zhang C, Gan L, Jin Y, Liu J, Wang T, Shen Y, Huang S, Zhang L, Zhang S, Chen P, Tong C, Kang J, Fan H, Zhou G, Xiang L, Wen Y, Gan R, Chen Y, Li X, Zhai L, Zhang Q, Ma D, Han Z, Hu Z.   +31 more
europepmc   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Human papillomavirus prevalence and genotypic characteristics among men in Wuhan, China: a cross-sectional study. [PDF]

BMC Infect Dis
Li Z, Wu R, Li Z, Fan H, Xiang L, Zhao L, Guo R, Xu S, Wu K, Zhu C.   +9 more
europepmc   +1 more source

Boosting Photo‐Pyroelectric Effect via Tunable Polarization and Interfacial Defect Engineering

Advanced Science, EarlyView.
This study reports Ba(Ti0.85Zr0.15)O3 nanocatalysts with enhanced polarization and oxygen‐vacancy‐rich interfaces for efficient NIR‐II photo‐pyroelectric therapy. Zr doping boosts the pyroelectric coefficient and accelerates polarization switching, while oxygen vacancies improve photothermal conversion and surface reactivity.
Yanli Huang, Haifen Luo, Jie Yin, Shuai Cao, Gaolei Dong, Zhi Tan, Chunlin Zhao, Peiye Wen, Fengwei Sun, Shan Zhang, Xianzeng Zhang, Yunlu Dai, Zhen Yang, Wei Huang   +13 more
wiley   +1 more source

AI-Assisted detection of corneal nerve structural abnormalities in early diabetic keratopathy: development and validation of a deep learning framework. [PDF]

Sci Rep
Pan J, Shi X, Wan L, Ke L, Yan Y, Mao J, Cong Y, Yang Z, Fang J, Wang Y, Xu C, Bao M, Zheng B, Gao L, Huang L, Yang Y.   +15 more
europepmc   +1 more source

NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation

Advanced Science, EarlyView.
NIBAN2, highly expressed in glioma stem‐like cells (GSCs), assembles with FLII and transcription factor RREB1 to form a nuclear complex. This complex transcriptionally activates stemness‐associated genes (e.g., CD44, NANOG) and metabolic enzymes (e.g., LDHA), thereby sustaining both transcriptional and metabolic stemness programs.
Liang liang Shi, Xinwei Qiao, Yue Hu, Minjie Wang, Shaojie Yu, Zihan Gong, Yuxin Rao, Hui Zheng, Siting Chen, Lin Li, Rong Fu, Tao Liang, Jin Yao, Xiaobing Jiang, Junjun Li   +14 more
wiley   +1 more source