Results 101 to 110 of about 5,290,731 (274)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Drought and heat stress tolerance screening in wheat using computed tomography

Plant Methods, 2020
Background Improving abiotic stress tolerance in wheat requires large scale screening of yield components such as seed weight, seed number and single seed weight, all of which is very laborious, and a detailed analysis of seed morphology is time ...
Jessica Schmidt, Joelle Claussen, Norbert Wörlein, Anja Eggert, Delphine Fleury, Trevor Garnett, Stefan Gerth   +6 more
doaj   +1 more source

Patterns of variability in Be/X-ray pulsars during giant outbursts

, 2013
The discovery of source states in the X-ray emission of black-hole binaries and neutron-star low-mass X-ray binaries constituted a major step forward in the understanding of the physics of accretion onto compact objects.
Acciari, Angelini, Axelsson, Balucinska-Church, Basko, Baykal, Becker, Becker, Becker, Belloni, Bradt, Caballero, Caballero, Churazov, Clark, Coburn, Coe, Coe, Corbit, Dachs, dal Fiume, Davies, Devasia, Di Salvo, Done, Doroshenko, Dunn, E. Nespoli, Ebisawa, Ebisawa, Ferrigno, Finger, Galloway, Galloway, Gierliński, Hasinger, Hayasaki, Heindl, Heindl, Homan, Içdem, James, Janot-Pacheco, Kendziorra, Klein-Wolt, Klochkov, Klochkov, Kreykenbohm, Körding, Levine, Li, Liedahl, Lin, Maitra, Makishima, Makishima, McBride, Mihara, Miyamoto, Muno, Naik, Nakajima, Nakajima, Negueruela, Negueruela, Nespoli, Nespoli, Nowak, Okazaki, Okazaki, P. Reig, Porter, Pottschmidt, Qu, Raichur, Reig, Reig, Reig, Reig, Reig, Reig, Reig, Reig, Revnivtsev, Reynolds, Rothschild, Shrader, Soong, Staubert, Staubert, Stella, Terada, Tsygankov, Tsygankov, Tsygankov, van der Klis, White, Wilson, Wilson, Yamauchi, Yan   +100 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Influence of metal–semiconductor interface treatments and absorber structure on the performance and reliability of uni-traveling-carrier photodiodes (UTC-PDs)

Scientific Reports
The effects of absorber structure–controlled by adjusting the thickness ratio of doped and undoped InGaAs layers–and metal-semiconductor interface treatment methods were investigated in waveguide-type UTC-PDs. Ultraviolet-ozone (UVO) and ammonia solution
Soo Cheol Kang, Jin Chul Cho, Eui Su Lee, Dong Woo Park   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A Transmissive X-ray Polarimeter Design For Hard X-ray Focusing Telescopes

, 2015
The X-ray Timing and Polarization (XTP) is a mission concept for a future space borne X-ray observatory and is currently selected for early phase study. We present a new design of X-ray polarimeter based on the time projection gas chamber.
Deng, Zhi, Dong, Yongwei, Feng, Hua, Han, Dong, He, Li, Heng, Peiyin, Ji, Jianfeng, Li, Hong, Li, Tenglin, Liu, Yinong, Lu, Fangjun, Wu, Qiong, Zeng, Ming, Zhang, Shuangnan   +13 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Automated detection of bone splinters in DEXA phantoms using deep neural networks

Current Directions in Biomedical Engineering, 2019
Dual energy radiographic imaging is a method to provide material information and can be used to differentiate between various tissue types. Dual energy X-ray absorption (DEXA) can be applied for breast density, osteoporosis or bone fracture analysis.
Rüger Steffen, Firsching Markus, Lucic Julija, Ennen Alexander, Uhlmann Norman, Wittenberg Thomas   +5 more
doaj   +1 more source