Results 111 to 120 of about 5,290,731 (274)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A Comparison of X-ray and Optical Emission in Cassiopeia A

, 2014
Broadband optical and narrowband Si XIII X-ray images of the young Galactic supernova remnant Cas A obtained over several decades are used to investigate spatial and temporal correlations on both large and small scales.
Fesen, Robert A., Patnaude, Daniel J.
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Current principles of effective therapy for ovarian cancer

Опухоли женской репродуктивной системы, 2015
In spite of all of modern medicine»s advances, ovarian cancer (OC) mortality remains to be incommensurably high and to hold the lead among gynecological cancers.
L. A. Ashrafyan, V. I. Kiselev, E. L. Muizhnek, E. V. Gerfanova, I. B. Antonova, I. N. Kuznetsov, O. I. Aleshikova   +6 more
doaj   +1 more source

INTEGRAL and Swift observations of IGRJ19294+1816 in outburst

, 2011
IGRJ19294+1816 was discovered by INTEGRAL in 2009 during a bright X-ray outburst and was classified as a possible Be X-ray binary or supergiant fast X-ray transient.
Bozzo, Bozzo, Bozzo, Buccheri, Burrows, C. Ferrigno, Corbet, Corbet, Corbet, Courvoisier, D’Aì, E. Bozzo, Ferrigno, Jenke, Krimm, Lebrun, Lund, M. Falanga, Markwardt, Press, R. Walter, Reig, Rodriguez, Rodriguez, Sguera, Sidoli, Strohmayer, Turler, Ubertini, Walter, Ziolkowski   +30 more
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Selected annotated instance segmentation sub-volumes from a large scale CT data-set of a historic aircraft

Scientific Data
The Me 163 was a Second World War fighter airplane and is currently displayed in the Deutsches Museum in Munich, Germany. A complete computed tomography (CT) scan was obtained using a large scale industrial CT scanner to gain insights into its history ...
Roland Gruber, Nils Reims, Andreas Hempfer, Stefan Gerth, Michael Böhnel, Theobald Fuchs, Michael Salamon, Thomas Wittenberg   +7 more
doaj   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Crystal structure, Hirshfeld surface analysis and DFT studies of (E)-1-(4-bromophenyl)-3-(3-fluorophenyl)prop-2-en-1-one

Acta Crystallographica Section E: Crystallographic Communications, 2019
The asymmetric unit of the title halogenated chalcone derivative, C15H10BrFO, contains two independent molecules, both adopting an s-cis configuration with respect to the C=O and C=C bonds. In the crystal, centrosymmetrically related molecules are linked
Muhamad Fikri Zaini, Ibrahim Abdul Razak, Mohamad Zahid Anis, Suhana Arshad   +3 more
doaj   +1 more source