Results 211 to 220 of about 424,805 (289)

SHMT2 modulates the transcriptome and metabolism profiles to promote the tumor phenotypes of bladder cancer HT-1376 cells. [PDF]

Front Genet
Guo X, Li G.
europepmc   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Author Correction: Treatment of liver cirrhosis using hepatocyte-derived liver progenitor-like cells: a prospective, open-label, single-arm, safety trial. [PDF]

Cell Discov
He K, Zhu XJ, Shi YP, Huang WJ, Yang TH, Xi ZF, Li QG, Sun HY, Qian LJ, Chen XS, Li PY, Zhou X, Gu GY, Li F, Liu WM, Chen CY, Zhao J, Wu HP, Yan FR, Ott M, Sharma AD, Liu H, Yu WF, Zhai B, Yan HX, Xia Q.   +25 more
europepmc   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source

Correction: Incidence rate and associated patient characteristics of liver disease in Wales 2004-2022: a retrospective population-scale observational study. [PDF]

BMJ Open
europepmc   +1 more source

Aberrant sialic acid metabolism promotes metabolic reprogramming and metastasis in breast cancer. [PDF]

Front Oncol
Yang L, Li Z, Wang M, Xiong X, Zhang S, Man Z, Dong C, Fu L.   +7 more
europepmc   +1 more source

Acceptance X-bar chart considering the sample distribution of capability indices, C ˆ p and C ˆ p k

, 2019
Pedro Carlos Oprime, Fabiane Letícia Lizarelli, Márcio Lopes Pimenta, Jorge Alberto Achcar   +3 more
openalex   +1 more source

PHR‐Mediated Pi Starvation Response Mobile Messenger RNAs Represent Noncoding Transcripts in Recipient Tissues

Advanced Science, EarlyView.
Mobile messenger RNAs (mRNAs) can travel long distances, serving as systemic signals that participate in plant growth and stress acclimation. This work determines that PHR proteins mediate the Pi starvation response (PSR)‐specific long‐distance transport of mRNAs and that these PSR‐specific mobile mRNAs represent noncoding transcripts in recipient ...
Weiguo Dong, Shuman Wang, Chao Liu, Lulu Qiao, Kai Liu, Qiongli Jin, Xiaorong Mo, Xingxing Shen, Keke Yi, Zhiye Wang   +9 more
wiley   +1 more source

BMP-2 gene-modified mesenchymal stem cells enhance tendon-bone healing in ACL reconstruction: a rabbit micro-CT and biomechanical study. [PDF]

BMC Surg
Zheng H, Zeng Y, Daoerji N, Wang H, Tang B, Shu L.   +5 more
europepmc   +1 more source

Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury

Advanced Science, EarlyView.
By integrating single‐cell RNA sequencing and spatial transcriptomics, tenascin C (TNC) is unveiled as a central organizer of the proinflammatory and profibrotic niche in kidney fibrosis. TNC promotes macrophage activation through TLR4/NF‐κB signaling, leading to renal inflammation and fibrosis.
Li Li, Jinlin Liao, Yuxi Zhang, Zifu Yao, Junxin Huang, Kejia Wu, Lu Li, Yiling Peng, Haili Zhu, Xue Hong, Xi Liu, Lili Zhou, Fan Fan Hou, Haiyan Fu, Youhua Liu   +14 more
wiley   +1 more source