Results 91 to 100 of about 9,343 (245)

The role of FGF23/Klotho in mineral metabolism and chronic kidney disease [PDF]

, 2013
Chronic kidney disease (CKD) is a global health burden of growing incidence and prevalence. As renal function declines disturbances in mineral metabolism, such as hyperphosphatemia and secondary hyperparathyroidism, inevitably develop. These metabolic
Olauson, Hannes
core   +1 more source

Burosumab in Unidentifiable Tumor‐Induced Osteomalacia

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Tumor‐induced osteomalacia (TIO) can be challenging due to underlying tumors being either unresectable or unidentifiable. Burosumab, an anti‐FGF23 monoclonal antibody, has been proven to be effective in treating TIO but is currently not subsidized for this indication in Australia.
Yi Shan Der, Santosh Chaubey, Anna Mclean, Yasmin Trinh, Shelley Pember, Ashim Sinha   +5 more
wiley   +1 more source

Genetic diseases of renal phosphate handling [PDF]

, 2017
UNLABELLED: Renal control of systemic phosphate homeostasis is critical as evident from inborn and acquired diseases causing renal phosphate wasting. At least three transport proteins are responsible for renal phosphate reabsorption: NAPI-IIa (SLC34A1 ...
Biber, Jürg, Hernando, Nati, Rubio-Aliaga, Isabel, Wagner, Carsten A.   +3 more
core   +3 more sources

Burosumab Provides Sustained Improvement in Phosphorus Homeostasis and Heals Rickets in Children Aged 1 to 4 Years With X-Linked Hypophosphatemia (XLH) [PDF]

, 2021
Gary S. Gottesman, Erik A. Imel, Thomas O. Carpenter, Angel Chen, Alison Skrinar, Mary Scott Roberts, Michael P. Whyte   +6 more
openalex   +1 more source

Pharmacokinetics and pharmacodynamics of a human monoclonal anti‐FGF23 antibody (KRN23) in the first multiple ascending‐dose trial treating adults with X‐linked hypophosphatemia [PDF]

, 2015
In X-linked hypophosphatemia (XLH), serum fibroblast growth factor 23 (FGF23) is increased and results in reduced renal maximum threshold for phosphate reabsorption (TmP), reduced serum inorganic phosphorus (Pi), and inappropriately low normal serum 1,25
Carpenter, Thomas O., Glorieux, Francis H., Humphrey, Jeffrey, Imel, Erik A., Insogna, Karl, Ito, Takahiro, Klausner, Mark A., Peacock, Munro, Portale, Anthony A., Ruppe, Mary D., Vergeire, Maria, Weber, Thomas J., Zhang, Xiaoping   +12 more
core   +1 more source

High Phosphate Load Induces De Novo Formation of Tertiary Lymphoid Structures in the Kidney

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
Graphical illustration of renal alterations under varying phosphate load: High phosphate load induces fibrosis, tubular injury, impaired renal function, and de novo formation of perivascular tertiary lymphoid structures. Under normal phosphate load, fibrosis, functional decline, and tubular injury are absent, while T‐ and B‐ cell aggregates are present
Nina Weingärtner, Beatrice Richter, Franziska Walles, Tamar Kapanadze, Jessica Schmitz, Jan H. Bräsen, Florian P. Limbourg, Dieter Haffner, Maren Leifheit‐Nestler   +8 more
wiley   +1 more source

Beyond Nutritional Deficiency: Persistent Rickets as a Manifestation of Vitamin D‐Dependent Rickets Type II in a Toddler

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Vitamin D‐dependent rickets type II (VDDR‐II) is a rare hereditary disorder caused by mutations in the vitamin D receptor gene, resulting in resistance to active vitamin D and impaired calcium absorption. We report a 2‐year and 6‐month‐old female toddler presenting with persistent rickets, delayed motor milestones, dental abnormalities, and ...
Abhisek Jha, Anil Yadav, Uma Shankar Jha, Preethuja Shah, Rohan Kumar Shah, Kuldeep Timilsina, Prabha Jha, Aabish Dahal, Saugat Bagale   +8 more
wiley   +1 more source

Hypophosphatemia in suspected seizures evaluated in first seizure clinics and neurology consults

Epilepsia Open, Volume 10, Issue 6, Page 2025-2031, December 2025.
Abstract Transient loss of consciousness (TLoC) is a leading cause of referrals to acute neurological services. A witness account is often lacking, and ancillary investigations are a critical diagnostic adjunct. Hypophosphatemia was recently identified as a potential marker of epileptic seizures in ward and emergency department presentations.
Sophie N. M. Binks, Daniil Zorkin, Bernard Liem, Arjune Sen   +3 more
wiley   +1 more source

X-linked hypophosphatemia due to a de novo novel splice-site variant in a 7-year-old girl with scaphocephaly, Chiari syndrome type I and syringomyelia

Bone Reports
X-linked hypophosphatemia (XLH) is a rare X-linked dominant inherited disorder caused by loss-of-function variants in the PHEX gene and characterized by renal phosphate wasting, hypophosphatemia, abnormal vitamin D metabolism, growth retardation and ...
Maria Fourikou, Aristea Karipiadou, Athina Ververi, Parthena Savvidou, Nikolaos Laliotis, Vassilios Tsitouras, Stella Stabouli, Emmanuel Roilides, Konstantinos Kollios   +8 more
doaj   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, Volume 1, Issue 3, Page 322-358, December 2025.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source