Results 111 to 120 of about 9,343 (245)

Effect of Increased Activity on Metabolic Markers in Captive Black Rhinos: A Pilot Study [PDF]

, 2009
Ex situ (captive) black rhinoceros populations exhibit higher rates of disease than free-ranging counterparts. Preliminary data from an ongoing study supports the association between excessive adipose tissue, iron overload, insulin resistance and ...
Bryk, Josephine M.
core  

Revisiting the Genetics of Hypophosphatasia

Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.
Overview of the genetic concepts in hypophosphatasia reviewed in this manuscript. ABSTRACT Hypophosphatasia (HPP) is a rare, inherited monogenic disorder that is typically caused by variants in the tissue‐nonspecific alkaline phosphatase (ALPL) gene.
Priya S. Kishnani, Catherine Rehder, Keiichi Ozono, Jordi Pérez‐López, Guillermo del Angel, William R. Mowrey, Meena Balasubramanian, Wolfgang Högler, Eric T. Rush   +8 more
wiley   +1 more source

FGF23 and Hypophosphatemic Rickets/Osteomalacia [PDF]

, 2022
Purpose of review X-linked hypophosphatemia and tumor-induced osteomalacia are diseases characterized by hypophosphatemia with impaired proximal tubular phosphate reabsorption.
Fukumoto, Seiji, Kawanami, Daiji, Takashi, Yuichi   +2 more
core  

Hyperparathyroidism and parathyroidectomy in X-linked hypophosphatemia patients

Bone, 2019
X-linked hypophosphatemia (XLH) causes rickets, osteomalacia, skeletal deformities and growth impairment, due to elevated fibroblast growth factor 23 and hypophosphatemia. Conventional therapy requires high doses of phosphate salts combined with active vitamin D analogues. Risks of this regimen include nephrocalcinosis and secondary hyperparathyroidism
Sean DeLacey, Ziyue Liu, Andrea Broyles, Sarah A. El-Azab, Cristian F. Guandique, Benjamin C. James, Erik A. Imel   +6 more
openaire   +3 more sources

Management of paediatric ulcerative colitis, part 1: Ambulatory care—An updated evidence‐based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation

Journal of Pediatric Gastroenterology and Nutrition, Volume 81, Issue 3, Page 765-815, September 2025.
Abstract Objectives Despite advances in the management of ambulatory paediatric ulcerative colitis (UC), challenges remain as many patients are refractory to therapy and some require colectomy. The aim of these guidelines is to provide an update on optimal care for UC through detailed recommendations and practice points. Methods These guidelines are an
Eytan Wine, Marina Aloi, Stephanie Van Biervliet, Jiri Bronsky, Javier Martín di Carpi, Marco Gasparetto, Laura Gianolio, Hannah Gordon, Iva Hojsak, Alexandra S. Hudson, Séamus Hussey, Johan van Limbergen, Erasmo Miele, Lorenzo Norsa, Ola Olén, Gianluca Pellino, Patrick van Rheenen, Lissy de Ridder, Richard K. Russell, Dror S. Shouval, Eunice Trindade, Dan Turner, David C. Wilson, Anat Yerushalmy Feler, Amit Assa   +24 more
wiley   +1 more source

FGF23, Hypophosphatemia, and Emerging Treatments

JBMR Plus, 2019
FGF23 is an important hormonal regulator of phosphate homeostasis. Together with its co‐receptor Klotho, it modulates phosphate reabsorption and both 1α‐hydroxylation and 24‐hydroxylation in the renal proximal tubules.
Erik A Imel, Andrew Biggin, Aaron Schindeler, Craig F Munns   +3 more
doaj   +1 more source

Phosphate, Fractures, and Frustration—A Missed Diagnosis of Oncogenic Osteomalacia Leading to Multisystem Complication

Clinical Case Reports, Volume 13, Issue 8, August 2025.
ABSTRACT Persistent hypophosphatemia must prompt thorough evaluation. This case highlights the severe, multisystem consequences of delayed recognition of oncogenic osteomalacia. Early biochemical assessment, imaging, and multidisciplinary involvement are critical to avoid misdiagnosis and prevent irreversible complications such as skeletal fragility ...
Ryan Michael Wilson, Lydia Sturridge
wiley   +1 more source

Reference Data and Predictors of HR‐pQCT‐Derived Muscle Density and Its Prediction of Physical Performance

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 4, August 2025.
ABSTRACT Background There is increasing awareness of a role for muscle composition in sarcopenia and cachexia. Computed tomography (CT)–based measures of muscle density (MusD) are commonly used to indicate composition, with a decrease in MusD reflecting an increase in muscle fat infiltration. The current study explored predictors of MusD acquired using
Stuart J. Warden, Ziyue Liu, Robyn K. Fuchs, Lilly G. Davisson, Keith G. Avin, Erik A. Imel, Kenneth Lim, Sharon M. Moe, Rachel K. Surowiec   +8 more
wiley   +1 more source

Decision letter for "Early Discrimination Between Tumor-Induced Rickets/Osteomalacia and X-Linked Hypophosphatemia in Chinese Children and Adolescents: A Retrospective Case-Control Study"

, 2021

openalex   +1 more source

Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease [PDF]

, 2015
Hepatitis B virus (HBV) infection is a dynamic state of interactions among HBV, hepatocytes, and the host immune system. Natural history studies of chronic hepatitis B (CHB) infection have shown an association between active viral replication and adverse
Farinati, Fabio, Gottardo, G, Rodr\uedguez Castro, K, Russo, FRANCESCO PAOLO, Scribano, L, Vanin, V   +5 more
core   +1 more source