Results 101 to 110 of about 4,392 (235)

Pharmacokinetics and pharmacodynamics of a human monoclonal anti‐FGF23 antibody (KRN23) in the first multiple ascending‐dose trial treating adults with X‐linked hypophosphatemia [PDF]

, 2015
In X-linked hypophosphatemia (XLH), serum fibroblast growth factor 23 (FGF23) is increased and results in reduced renal maximum threshold for phosphate reabsorption (TmP), reduced serum inorganic phosphorus (Pi), and inappropriately low normal serum 1,25
Carpenter, Thomas O., Glorieux, Francis H., Humphrey, Jeffrey, Imel, Erik A., Insogna, Karl, Ito, Takahiro, Klausner, Mark A., Peacock, Munro, Portale, Anthony A., Ruppe, Mary D., Vergeire, Maria, Weber, Thomas J., Zhang, Xiaoping   +12 more
core   +1 more source

Relationships between matrix mineralization, oxidative metabolism, and mitochondrial structure during ATDC5 murine chondroprogenitor cell line differentiation

Journal of Cellular Physiology, Volume 239, Issue 8, August 2024.
Abstract The mechanistic relationships between the progression of growth chondrocyte differentiation, matrix mineralization, oxidative metabolism, and mitochondria content and structure were examined in the ATDC5 murine chondroprogenitor cell line. The progression of chondrocyte differentiation was associated with a statistically significant (p ≤ 0.05) 
Kevin Blank, Derrick Ekanayake, Margaret Cooke, Beth Bragdon, Amira Hussein, Louis Gerstenfeld   +5 more
wiley   +1 more source

Fosfaattiaineenvaihdunnan säätely ja häiriöt [PDF]

, 2016
•La­bo­ra­to­riossa mi­tattu plasman fos­fori ku­vaa pääo­sin fos­faattia. Klii­ni­sessä työs­sä ter­mejä ”fos­fori” ja ”fos­faatti” käy­tetään usein syno­nyy­meinä. •Plasman fos­faatti hei­jastaa huo­nosti ko­ko ke­hon fosfaat­ti­va­ras­toja.
Koistinen, Heikki, Miettinen, Helena
core  

Association between blood markers and the progression of osseointegration in percutaneous prostheses patients—A pilot study

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 112, Issue 3, March 2024.
Abstract Patients implanted with osseointegrated (OI) prosthetic systems have reported vastly improved upper and lower extremity prosthetic function compared with their previous experience with socket‐suspension systems. However, OI systems have been associated with superficial and deep‐bone infections and implant loosening due, in part, to a failure ...
Andrew Miller, Sujee Jeyapalina, Jayant P. Agarwal, James Peter Beck   +3 more
wiley   +1 more source

The impact of metabolic disorders on management of periodontal health in children

Pediatric Discovery, Volume 2, Issue 1, March 2024.
Metabolic diseases in children and adolescents may increase the risk of periodontal disease by affecting immunity and oral microbial colonization. Abstract Periodontitis is a chronic inflammatory disease caused by plaque biofilm which shares risk factors with systemic chronic diseases such as diabetes, cardiovascular disease, and osteoporosis.
Yunyan Zhang, Tong‐Chuan He, Hongmei Zhang   +2 more
wiley   +1 more source

Intact fibroblast growth factor 23 and fragments in plasma from Gambian children [PDF]

, 2012
SUMMARY: Fibroblast growth factor 23 (FGF23) is grossly elevated in Gambian children with rickets and, at a lower prevalence, in those without bone deformities.
A. Prentice, S. F. A. Bruggraber, V. Braithwaite   +2 more
core   +1 more source

Current situation and prospect for the diagnosis and treatment of pediatric critical rare diseases in China

Pediatric Investigation, Volume 8, Issue 1, Page 66-71, March 2024.
Children with critical rare diseases often have multiple organ dysfunction and high mortality. At present, there are some problems in the diagnosis and treatment of critical rare diseases of children in China, such as long diagnosis time, high misdiagnosis rate, limited treatment methods, and heavy disease burden.
Yingchao Liu, Suyun Qian
wiley   +1 more source

A bibliometric approach to worldwide scientific production of familial hypophosphataemic rickets in Scopus (2000–2022)

Orphanet Journal of Rare Diseases
Background Familial hypophosphatemic rickets are disabling conditions that negatively impact physical functioning, activities of daily living, mental health and social life.
Frank Hernández-García, Helena Gil-Peña, José M. López, Rocío Fuente, Patricia Oro Carbajosa, Ibraín Enrique Corrales-Reyes, Julián Rodríguez Suárez   +6 more
doaj   +1 more source

Analysis of Thisbe and Pyramus functional domains reveals evidence for cleavage of Drosophila FGFs [PDF]

, 2010
Background: As important regulators of developmental and adult processes in metazoans, Fibroblast Growth Factor (FGF) proteins are potent signaling molecules whose activities must be tightly regulated.
Stathopoulos, Angelike, Tulin, Sarah
core   +4 more sources

Long-term renal function and hypertension in adult survivors of childhood sarcoma [PDF]

, 2018
Aim: Little data is available on long-term renal impairment in survivors from childhood sarcoma. We investigated the prevalence of renal impairment and hypertension after very long-term follow-up in survivors who reached adulthood after treatment for ...
Andreoli, Gianmarco, Bonci, Enea, Celani, Camilla, Marrucci, Oriana, Pedetti, Valeria, Schiavetti, Amalia, Varrasso, Giulia   +6 more
core   +1 more source