Results 61 to 70 of about 2,319,252 (294)
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
X-ray beam diagnostics at the MID instrument of the European X-ray Free-Electron Laser Facility
Journal of Synchrotron RadiationThe Materials Imaging and Dynamics (MID) instrument at the European X-ray Free-Electron Laser Facility (EuXFEL) is equipped with a multipurpose diagnostic end-station (DES) at the end of the instrument.
Ulrike Boesenberg +19 more
doaj +1 more source
The hard X-ray perspective on the soft X-ray excess [PDF]
, 2014 The X-ray spectra of many active galactic nuclei (AGN) exhibit a `soft excess' below 1keV, whose physical origin remains unclear. Diverse models have been suggested to account for it, including ionised reflection of X-rays from the inner part of the ...
Fabian, Andrew C. +7 more
core +4 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Scientific ReportsDeep learning-based image analysis offers great potential in clinical practice. However, it faces mainly two challenges: scarcity of large-scale annotated clinical data for training and susceptibility to adversarial data in inference.
Wai Yan Ryana Fok +7 more
doaj +1 more source
IMAGING TECHNIQUES IN THE DIFFERENTIAL DIAGNOSIS OF PARASITIC LUNG DISEASES AND LUNG CANCER
Сибирский онкологический журнал, 2016 We analyzed imaging findings of 18 patients with atypical manifestations of parasitic diseases of the lung, who were admitted to the hospital with suspected lung cancer or metastatic lung cancer.
P. M. Kotlyarov, N. I. Sergeev
doaj +1 more source
The radio/X-ray correlation in X-ray binaries - Insights from a hard X-ray perspective [PDF]
, 2018 The radio/X-ray correlation is one of the most important pieces of observational evidence of the disk-jet connection in accreting compact objects. However, a growing number of X-ray binaries seem to present deviations from the universal radio/X-ray correlation and the origin of these outliers are still very much debated.
arxiv +1 more source
, 2016 X-ray pulsars shine thanks to the conversion of the gravitational energy of accreted material to X-ray radiation. The accretion rate is modulated by geometrical and hydrodynamical effects in the stellar wind of the pulsar companions and/or by instabilities in accretion discs.
Roland Walter, Carlo Ferrigno
openaire +2 more sources
FEBS Letters, EarlyView.α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source
Efficient overall water splitting in acid with anisotropic metal nanosheets
Nature Communications, 2021 Ru is one of the most active metals for oxygen evolution reaction, but it quickly dissolves in acidic electrolyte particularly in nanosized form. Here, the authors show that coral-like solid-solution Ru‒Ir consisting of 3 nm-thick sheets with only 6 at ...
Dongshuang Wu +16 more
doaj +1 more source