Results 41 to 50 of about 10,303 (249)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Formation of electron bunches for harmonic cascade x-ray free electron lasers

Physical Review Special Topics. Accelerators and Beams, 2006
Specific requirements for the electron beam in harmonic cascade-free electron lasers, together with means to produce such beams, are presented. All results are illustrated with simulations and particle tracking studies.
M. Cornacchia, S. Di Mitri, G. Penco, A. A. Zholents   +3 more
doaj   +1 more source

X-ray free electron laser: opportunities for drug discovery [PDF]

Essays in Biochemistry, 2017
Past decades have shown the impact of structural information derived from complexes of drug candidates with their protein targets to facilitate the discovery of safe and effective medicines. Despite recent developments in single particle cryo-electron microscopy, X-ray crystallography has been the main method to derive structural information.
Robert K Y, Cheng, Rafael, Abela, Michael, Hennig   +2 more
openaire   +3 more sources

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Optical Shaping of X-Ray Free-Electron Lasers

Physical Review Letters, 2016
In this Letter we report the experimental demonstration of a new temporal shaping technique for x-ray free-electron lasers (FELs). This technique is based on the use of a spectrally shaped infrared (IR) laser and allows optical control of the x-ray generation process.
A, Marinelli, R, Coffee, S, Vetter, P, Hering, G N, West, S, Gilevich, A A, Lutman, S, Li, T, Maxwell, J, Galayda, A, Fry, Z, Huang   +11 more
openaire   +3 more sources

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source

At-wavelength characterization of X-ray wavefronts in Bragg diffraction from crystals

Journal of Synchrotron Radiation, 2023
The advent of next-generation synchrotron radiation sources and X-ray free-electron lasers calls for high-quality Bragg-diffraction crystal optics to preserve the X-ray beam coherence and wavefront.
Xianbo Shi, Zhi Qiao, Paresh Pradhan, Peifan Liu, Lahsen Assoufid, Kwang-Je Kim, Yuri Shvyd'ko   +6 more
doaj   +1 more source

Numerical Simulations of X-Ray Free Electron Lasers (XFEL) [PDF]

Multiscale Modeling & Simulation, 2014
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Paolo Antonelli, Agissilaos Athanassoulis, Zhongyi Huang, Peter A. Markowich   +3 more
openaire   +2 more sources

Creating Ti–Fe α/β Alloys by Diffusion‐Driven Solid‐State Processing

Advanced Engineering Materials, EarlyView.
This study proposes making alloys containing fast diffusing elements that are difficult to produce by ingot metallurgy, by diffusion‐driven solid‐state HIP processing of elemental powders and low‐temperature homogenisation. Here, novel Fe‐Ti α–β alloys are formed having fine α–β lamellae, a small β prior grain size without significant intermetallics ...
Jiaqi Xu, Xun Zhang, Jack M. Donoghue, Albert D. Smith, Rahul Unnikrishnan, Rhys Thomas, Vahid Nekouie, Jie Luo, Dongchen Hu, Michael Preuss, Philip J. Withers   +10 more
wiley   +1 more source

Relativistic x-ray free-electron lasers in the quantum regime [PDF]

Physical Review E, 2012
We present a nonlinear theory for relativistic X-ray free electron lasers in the quantum regime, using a collective Klein-Gordon (KG) equation (for relativistic electrons), which is coupled with the Maxwell-Poisson equations for the electromagnetic and electrostatic fields.
Eliasson, Bengt, Shukla, Padma
openaire   +5 more sources