Results 1 to 10 of about 216 (89)

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source

Cis–Trans Rotational Isomerism of Formic Acid, Sulfur, and Selenium Analogues and Their Dimers: Chemical Kinetics Under Interstellar Conditions

International Journal of Chemical Kinetics, EarlyView.
ABSTRACT We present chemical kinetic rate constants for the cis to trans isomerisation or rotamerization of monomeric seleno‐, thio‐, and formic acids and that of three of their dimeric species, based on variational transition state theory and multidimensional tunneling calculations in the gas‐phase, from 10 K to 300 K. These provide, firstly, reliable
Judith Wurmel, John M. Simmie
wiley   +1 more source

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

50% body weight loading reduces stature increases and lumbar disc expansion from 4 h hyper‐buoyancy floatation versus 15 min sitting upright

Experimental Physiology, EarlyView.
Abstract Microgravity is associated with stature increases, back pain and post‐flight intervertebral disc (IVD) herniation. This study aims to determine whether 30 s seated 50% body weight (BW) axial loading is comparable to 15 min sitting upright in 1 g upon changes in stature, anterior lumbar IVD height (via ultrasound), passive vertebral stiffness ...
David Marcos‐Lorenzo, Christina Lysandrou, Laura Sudres, Alfonso Gil‐Martinez, Jaap Swanenburg, James Edward Clark, David Andrew Green   +6 more
wiley   +1 more source

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

MUC1 as a Survival Effector of Radiotherapy‐Induced Epithelial Hybrid States in Basal‐Like Breast Cancer

International Journal of Cancer, Volume 159, Issue 5, Page 1296-1310, 1 September 2026.
Basal‐like breast cancer (BLBC) is aggressive and often exhibits inherent or acquired resistance to radiotherapy (RT), a primary treatment option. RT resistance is underpinned by molecular alterations, many of which are poorly understood. Here, RT‐induced transcriptomic changes were analyzed using bulk and spatial sequencing in a BLBC mouse model and ...
Garyfallia Pantelaiou‐Prokaki, Husam Bamahmoud, Nadine S. Georges, Shaishavi Jansari, Annika Jung, Daniela Grimm, Evangelos Prokakis, Fabian Alexander Gayer, Maryam Deldar, Christian Dullin, Julia Gallwas, Florian Wegwitz, Frauke Alves   +12 more
wiley   +1 more source

Collisionless Shocks: Contemporary State After Three Quarters of a Century of Research

Reviews of Geophysics, Volume 64, Issue 3, September 2026.
Abstract The collisionless shock research started in the late 1950s. Since then, plenty of data have been accumulated due to the large number of missions in the heliosphere, providing in situ measurements of the fields and particles. The quality of these measurements has vastly improved, especially in the last two decades.
M. Gedalin, M. Balikhin, V. Krasnoselskikh   +2 more
wiley   +1 more source

Solvent‐Guided Chiral Assemblies and Chemical Doping of OEG‐Functionalized Conjugated Polymers

Advanced Materials, Volume 38, Issue 45, 13 August 2026.
Solvent‐dependent aggregation pathways dictate whether conjugated polymers form chiral lyotropic liquid‐crystalline assemblies or achiral packed aggregates. Mapping solvent‐controlled β₁ and β2 states reveals that weaker backbone association favors β₁ aggregates and reorganizable twisted mesophases, whereas stronger backbone association favors β2 ...
Sanghyun Jeon, Justin Scott Neu, Nahyun Ahn, Ayse Senlik, Yen‐Chi Chen, Pravini S. Fernando, Priyotosh Bairagya, Chetan Kumar Prasad, Janice Mihyun Baek, Wei You, Ying Diao   +10 more
wiley   +1 more source

Latitude Survey of Neutrons and Muons to Determine Cosmic Ray Neutron Sensing Yield Functions

Journal of Geophysical Research: Space Physics, Volume 131, Issue 8, August 2026.
Abstract Cosmic Ray Neutron Sensing (CRNS) is a ground‐based technique that utilizes epithermal neutron measurements as a proxy for environmental hydrogen content. Similarly to other ground‐based cosmic ray detectors (e.g., neutron monitors), CRNS detectors are affected by the solar cycle and space weather events.
Lasse Hertle, Fraser Baird, Ulrich Schmidt, Bernd Heber, Michael Walter, Nora Krebs, Paul Schattan, Pauli Väisänen, Peter Dietrich, Steffen Zacharias, Solveig Landmark, Daniel Rasche, Marco Kossatz, Gary Womack, Steve Hamann, Enrico Gazzola, Martin Schrön   +16 more
wiley   +1 more source

Low Frequency Extensions of Cyclotron Maser Instability‐Generated Radio Emission: A Statistical View From Cassini at Saturn

Journal of Geophysical Research: Space Physics, Volume 131, Issue 8, August 2026.
Abstract The Cassini spacecraft spent 13 years orbiting Saturn, quasi‐continuously measuring Saturn's radio emissions. One of the key elements of the radio spectrum at Saturn is the Saturn Kilometric Radiation (SKR), and several studies have been written on events called Low Frequency Extensions (LFEs) which represent strong, continuous extensions of ...
C. M. Jackman, A. R. Fogg, S. W. H. Cowley, G. Provan, H. Adamski, N. M. Besch, D. M. Hollman, S. Walker, M. J. Rutala, L. Lamy, C. K. Louis, E. P. O’Dwyer   +11 more
wiley   +1 more source