Results 151 to 160 of about 535,016 (293)

Fertility issues and pregnancy outcomes in females with partial X-chromosome deletions: a retrospective observational cohort study. [PDF]

BMC Pregnancy Childbirth
Li XT, Dai Y, Chen JY, Cai MJ, Yao XM, Ge YS.   +5 more
europepmc   +1 more source

XWAS: A Software Toolset for Genetic Data Analysis and Association Studies of the X Chromosome [PDF]

, 2015
Feng Gao, Diana Chang, Arjun Biddanda, Li Ma, Yingjie Guo, Zilu Zhou, Alon Keinan   +6 more
openalex   +1 more source

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels. [PDF]

Nat Commun
Allsop RN, Boeren J, Tan BF, Merzouk S, Poovanthingal S, van IJcken WFJ, Demmers JAA, Mira Bontenbal H, Gontan C, Gribnau J, Pasque V.   +10 more
europepmc   +1 more source

Nonsense Mutations in SMPX, Encoding a Protein Responsive to Physical Force, Result in X-Chromosomal Hearing Loss [PDF]

, 2011
Antje K. Huebner, Marta Gandía, Peter Frommolt, A Maak, Eva M. Wicklein, Hölger Thiele, Janine Altmüller, Florian Wagner, Antonio Viñuela, Luis A. Aguirre, Felipe Moreno, H. Maier, Isabella Rau, Sebastian Gießelmann, Gudrun Nürnberg, Andreas Gal, Peter Nürnberg, Christian A. Hübner, Ignacio del Castillo, Ingo Kurth   +19 more
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Escape From X Chromosome Inactivation as a Driver of Plasmacytoid DC Heterogeneity in Health and Disease. [PDF]

Immunol Rev
Barrat FJ, Guéry JC.
europepmc   +1 more source

siRNAs from an X-linked satellite repeat promote X-chromosome recognition in Drosophila melanogaster [PDF]

, 2014
Debashish U. Menon, Cristian Coarfa, Weimin Xiao, Preethi H. Gunaratne, Victoria H. Meller   +4 more
openalex   +1 more source

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

Nonrandom X Chromosome Inactivation Is Influenced by Multiple Regions on the Murine X Chromosome [PDF]

, 2012
Joanne L. Thorvaldsen, Christopher Krapp, Huntington F. Willard, Marisa S. Bartolomei   +3 more
openalex   +1 more source