Results 161 to 170 of about 6,270,911 (362)
Advanced Science, EarlyView.These findings elucidate the innovative role of HIC1 as a transcriptional activator in GC, driving the initiation of pyroptosis and enhancing CD8+ T cell infiltration, which has certain novelty and creative significance. Collectively, targeting HIC1 can present an appealing immunotherapeutic strategy to improve outcomes in GC patients.
Mengjie Kang +4 more
wiley +1 more source
The toll like receptor 7 pathway and the sex bias of systemic lupus erythematosus
Frontiers in ImmunologySystemic lupus erythematosus (SLE) predominately affects women with a ratio of females-to-males of about 9:1. The complement of sex chromosomes may play and important role in the mechanism of the sex bias.
R. Hal Scofield +6 more
doaj +1 more source
Relative Effects of X-Rays and Neutrons on Chromosomes in Different Parts of the “Resting Stage” [PDF]
, 1942 Alfred Marshak
openalex +1 more source
Advanced Science, EarlyView.Researchers develop advanced tools to study grapevine traits like berry quality and stress resilience. A 200K SNP array and high‐throughput phenotyping enable the identification of loci linked to berry shape, sugar content, acidity, and cold tolerance. Functional validation of genes such as NAC08 reveals roles in cold tolerance.
Yuyu Zhang +11 more
wiley +1 more source
PROOF THAT THE ENTIRE CHROMOSOME IS NOT ELIMINATED IN THE PRODUCTION OF SOMATIC VARIATIONS BY X-RAYS IN DROSOPHILA [PDF]
, 1930 J. T. Patterson
openalex +1 more source
Advanced Science, EarlyView.Lysine demethylase 6A (KDM6A), an epigenetic regulator expressed in hematopoietic stem and progenitor cells (HSPCs), plays a critical role in hematopoietic homeostasis. Deficiency of KDM6A induces myeloid lineage skewing and drives the development of a chronic myelomonocytic leukemia (CMML)‐like disease.
Huiqiao Chen +11 more
wiley +1 more source
X Chromosome Inactivation in Opioid Addicted Women
Basic and Clinical Neuroscience, 2015 Introduction: X chromosome inactivation (XCI) is a process during which one of the two X chromosomes in female human is silenced leading to equal gene expression with males who have only one X chromosome.
Nasim Vousooghi +4 more
doaj
CROSSING OVER NEAR THE SPINDLE ATTACHMENT OF THE X CHROMOSOMES IN ATTACHED-X TRIPLOIDS OF DROSOPHILA MELANOGASTER [PDF]
, 1935 G W Beadle
openalex +1 more source
Advanced Science, EarlyView.Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du +8 more
wiley +1 more source