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Chromosome imprinting and the mammalian X chromosome
Nature, 1975Chromosome imprinting is the process by which one of two genetically homologous chromosomes is predetermined to function differently from the other at a subsequent stage in development. In the coccid insects, imprinting occurs in the egg, at the time of fertilisation; it probably occurs at the same time and site in mammals, and possibly also in Sciara.
H S, Chandra, S W, Brown
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Mammalian X Chromosome Inactivation
1992The initial step in mammalian sexual differentiation is based on the XX: XY chromosomal system. In order to function properly, this chromosomal mechanism must be regulated to eliminate the aneuploidy effects in somatic tissues and still insure normal sexual differentiation and development.
S M, Gartler, K A, Dyer, M A, Goldman
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X Chromosome and Ovarian Failure
Seminars in Reproductive Medicine, 2007Genes for reproduction are enriched on the sex chromosomes and they may be involved in the many forms of X- or Y-linked infertility. Here we review the X-linked disorders of ovulation and we show that despite the relatively frequent observation of X chromosome rearrangements in women with ovarian dysgenesis or ovarian failure, the search for X-linked ...
Toniolo, Daniela, RIZZOLIO, Flavio
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Human Genetics, 1983
Starting with the male chiasma distribution for chromosome 2, a significantly better fit is obtained to lod scores for the X chromosome if terminalization of distal chiasmata is assumed. The linkage data are not consistent with a uniform distribution of chiasmata, absence of terminalization, or restriction of terminalization to the distal band.
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Starting with the male chiasma distribution for chromosome 2, a significantly better fit is obtained to lod scores for the X chromosome if terminalization of distal chiasmata is assumed. The linkage data are not consistent with a uniform distribution of chiasmata, absence of terminalization, or restriction of terminalization to the distal band.
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Presse medicale (Paris, France : 1983), 2007
X and Y chromosomes hove evolved from a common proto-chromosome, 300 million years ago. They shore 29 genes, scottered in two homologous regions (PAR1 and PAR2). Ten per cent of humon genetic diseases result from mutations of X-linked genes. Disorders with mental handicap, muscle involvement or infertility ore overrepresented. X chromosome inactivation
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X and Y chromosomes hove evolved from a common proto-chromosome, 300 million years ago. They shore 29 genes, scottered in two homologous regions (PAR1 and PAR2). Ten per cent of humon genetic diseases result from mutations of X-linked genes. Disorders with mental handicap, muscle involvement or infertility ore overrepresented. X chromosome inactivation
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1985
Female mammals have two X-chromosomes, but male mammals have only one X-chromosome. This could result in females having twice as many X-chromosome transcripts as males, but this does not occur because one of the X-chromosomes is largely inactive. (The tip of the short arm of both X-chromosomes is active.) The inactive X-chromosome is highly condensed ...
Roger L. P. Adams, Roy H. Burdon
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Female mammals have two X-chromosomes, but male mammals have only one X-chromosome. This could result in females having twice as many X-chromosome transcripts as males, but this does not occur because one of the X-chromosomes is largely inactive. (The tip of the short arm of both X-chromosomes is active.) The inactive X-chromosome is highly condensed ...
Roger L. P. Adams, Roy H. Burdon
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