Results 281 to 290 of about 6,305,601 (337)

Escape from X-chromosome inactivation at KDM5C is driven by promoter-proximal DNA elements and enhanced by domain context. [PDF]

Hum Mol Genet
Peeters S, Baldry S, Korecki AJ, Srinivasan A, Wasserman WW, Simpson EM, Brown CJ.   +6 more
europepmc   +1 more source

Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
Lung squamous cell cancer (LUSC) is deadly due to lack of good treatments. Here, multiomics techniques are applied to LUSC tumors and find thousands of cancer‐specific enhancers controlling key genes. Interestingly, the gene PTPRZ1 is identified as a critical oncogene driven by the LUSC‐acquired enhancers. PTPRZ1 is activated by MDK, fueling cancer via
Yong‐Qiang Ning, Jie Wang, Yihui Zhang, Hongrui Li, Zenan Jiang, Xinyu Su, Xiao Yang, Xiaoxuan Wu, Bing Wei, Jianmin Ying, Jian Yan, Wenbin Li   +11 more
wiley   +1 more source

Female-bias in systemic lupus erythematosus: How much is the X chromosome to blame? [PDF]

Biol Sex Differ
Vieira AA, Almada-Correia I, Inácio J, Costa-Reis P, da Rocha ST.   +4 more
europepmc   +1 more source

A Coding SNP in GmPM30 Enhances Soybean Salinity Tolerance and Yield through the GmLEA1‐GmPM30‐GmLEC1 Module

Advanced Science, EarlyView.
A natural variation in soybean PM30, GmPM30‐HapT, confers greater salt tolerance than GmPM30‐HapC via stronger GmLEA1‐GmPM30‐GmLEC1 interactions. Pyramiding their elite haplotypes yields additive gains in salt tolerance and yield, establishing a novel workflow linking evolutionary genomics, molecular mechanisms, and breeding applications via the module
Shiyu Huang, Yuhan Xia, Jingting Yang, Yujun Si, Xue Chen, Hao Zhang, Tianshi Liu, Wenyu Zheng, Xin Chen, Zhongjuan Zhao, Xiaojian Zheng, Qing Lu, Shuo Li, Fengning Xiang   +13 more
wiley   +1 more source

A Novel Large Duplication on the X Chromosome as a Cause of Familial Generalized Dystonia: A Case Report. [PDF]

Int J Mol Sci
Costa A, Pereira D, Malaquias MJ, Brandão AF, Oliveira J, Magalhães M.   +5 more
europepmc   +1 more source

HTGTS‐TCR‐Seq for Profiling of Mouse and Human T‐Cell Receptor α and β Gene Rearrangements and Diversity

Advanced Science, EarlyView.
HTGTS‐TCR‐seq is an efficient and cost‐effective method for profiling TCRα and TCRβ rearrangements using only a few primers. It captures both productive and nonproductive recombination events, minimizes primer bias, and reveals stage‐specific and age‐related repertoire changes in mice, as well as conserved features in human peripheral T cells ...
Rui Luo, Yawei Song, Meichen Wang, Longhao Zou, Fangtai Jiao, Tiange Yang, Guangchuan Wang, Zhuoyi Liang, Wei Wu, Hai‐Qiang Dai   +9 more
wiley   +1 more source

Role of the X Chromosome in Alzheimer Disease Genetics.

JAMA Neurol
Belloy ME, Le Guen Y, Stewart I, Williams K, Herz J, Sherva R, Zhang R, Merritt V, Panizzon MS, Hauger RL, Gaziano JM, Logue M, Napolioni V, Greicius MD.   +13 more
europepmc   +1 more source

SRY+ Derivative X Chromosome in a Female With Apparently Typical Sexual Development. [PDF]

Mol Genet Genomic Med
Brewer CJ, Coyan AG, Smith N, Jones B, Smolarek TA, Liu J.   +5 more
europepmc   +1 more source

An investigation of a hemophilia A female with heterozygous intron 22 inversion and skewed X chromosome inactivation. [PDF]

Front Genet
Tan X, Yang Y, Wu X, Zhu J, Wang T, Jiang H, Chen S, Lou S.   +7 more
europepmc   +1 more source