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The X chromosome in space

Nature Reviews Genetics, 2017
Extensive 3D folding is required to package a genome into the tiny nuclear space, and this packaging must be compatible with proper gene expression. Thus, in the well-hierarchized nucleus, chromosomes occupy discrete territories and adopt specific 3D organizational structures that facilitate interactions between regulatory elements for gene expression.
Teddy Jégu, Eric Aeby, Jeannie T. Lee
semanticscholar   +3 more sources

Chromosome imprinting and the mammalian X chromosome [PDF]

open access: possibleNature, 1975
Chromosome imprinting is the process by which one of two genetically homologous chromosomes is predetermined to function differently from the other at a subsequent stage in development. In the coccid insects, imprinting occurs in the egg, at the time of fertilisation; it probably occurs at the same time and site in mammals, and possibly also in Sciara.
Spencer W. Brown, H. Sharat Chandra
openaire   +2 more sources

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