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Annual Review of Biochemistry, 2018
X chromosome regulation represents a prime example of an epigenetic phenomenon where coordinated regulation of a whole chromosome is required. In flies, this is achieved by transcriptional upregulation of X chromosomal genes in males to equalize the gene
Maria Samata, A. Akhtar
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X chromosome regulation represents a prime example of an epigenetic phenomenon where coordinated regulation of a whole chromosome is required. In flies, this is achieved by transcriptional upregulation of X chromosomal genes in males to equalize the gene
Maria Samata, A. Akhtar
semanticscholar +1 more source
Pathology, 1983
Publisher Summary The fragile X chromosome is associated with a common form of X-linked mental retardation in males and possibly females. The fragile X is so called because it has a fragile site at the distal end of the long arm. Fragile sites are morphological features of chromosomes defined as specific points liable to show some specific features ...
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Publisher Summary The fragile X chromosome is associated with a common form of X-linked mental retardation in males and possibly females. The fragile X is so called because it has a fragile site at the distal end of the long arm. Fragile sites are morphological features of chromosomes defined as specific points liable to show some specific features ...
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Science, 1995
In many species, females possess two X chromosomes and males have one X chromosome. This difference is critical for the initial determination of sex. However, the X encodes many functions required equally in males and females; thus, X chromosome expression must be adjusted to compensate for the difference in dosage between the sexes ...
Mitzi I. Kuroda, Richard L. Kelley
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In many species, females possess two X chromosomes and males have one X chromosome. This difference is critical for the initial determination of sex. However, the X encodes many functions required equally in males and females; thus, X chromosome expression must be adjusted to compensate for the difference in dosage between the sexes ...
Mitzi I. Kuroda, Richard L. Kelley
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Current Opinion in Pediatrics, 2001
The biology of the X chromosome is unique, as there are two Xs in females and only a single X in males, whereas the autosomes are present in duplicate in both sexes. The presence of only a single autosome, which can occur as a result of an error in meiotic segregation, is invariably an embryonic lethal event.
Michael A. Goldman, Stanley M. Gartler
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The biology of the X chromosome is unique, as there are two Xs in females and only a single X in males, whereas the autosomes are present in duplicate in both sexes. The presence of only a single autosome, which can occur as a result of an error in meiotic segregation, is invariably an embryonic lethal event.
Michael A. Goldman, Stanley M. Gartler
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Digging into X chromosome inactivation
Science, 2021Characterizing X chromosome inactivation in nonhuman primates reveals some ...
Rougeulle, C., Heard, Edith
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Annals of Internal Medicine, 1962
The history of our knowledge of the X chromosome of man is reviewed with appropriate reference to the contributions made through study of other forms. It is noteworthy that sex-linkage was first observed in man. X-linkage has been established for about 60 traits in man.
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The history of our knowledge of the X chromosome of man is reviewed with appropriate reference to the contributions made through study of other forms. It is noteworthy that sex-linkage was first observed in man. X-linkage has been established for about 60 traits in man.
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The X chromosome and the ovary*1
Journal of the Society for Gynecologic Investigation, 2001X chromosome abnormalities are the leading identifiable cause of premature ovarian failure (POF). POF-related abnormalities range from the complete absence of one X chromosome to assorted deletions and translocations to mutations in specific genes.
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BioEssays, 2001
AbstractThere is new and convincing evidence(1) that the mammalian X chromosome, as well as the Y chromosome, contains an atypically high proportion of genes involved in sex and reproduction (SRR genes). Here we consider alternative explanations for this concentration.
Margaret L. Delbridge +1 more
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AbstractThere is new and convincing evidence(1) that the mammalian X chromosome, as well as the Y chromosome, contains an atypically high proportion of genes involved in sex and reproduction (SRR genes). Here we consider alternative explanations for this concentration.
Margaret L. Delbridge +1 more
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Inactivation of the X-Chromosome
New England Journal of Medicine, 1972IN its classic form, the hypothesis of X-chromosome inactivation holds that only one of the two X-chromosomes present in cells of female mammals is functional. The "decision" of which X-chromosome is to operate in a cell occurs quite early in embryogenesis and, once made, is irreversible for that cell and all its progeny.
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