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Nature Reviews Genetics, 2017
Extensive 3D folding is required to package a genome into the tiny nuclear space, and this packaging must be compatible with proper gene expression. Thus, in the well-hierarchized nucleus, chromosomes occupy discrete territories and adopt specific 3D organizational structures that facilitate interactions between regulatory elements for gene expression.
Teddy Jégu, Eric Aeby, Jeannie T. Lee
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Extensive 3D folding is required to package a genome into the tiny nuclear space, and this packaging must be compatible with proper gene expression. Thus, in the well-hierarchized nucleus, chromosomes occupy discrete territories and adopt specific 3D organizational structures that facilitate interactions between regulatory elements for gene expression.
Teddy Jégu, Eric Aeby, Jeannie T. Lee
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Science, 1995
In many species, females possess two X chromosomes and males have one X chromosome. This difference is critical for the initial determination of sex. However, the X encodes many functions required equally in males and females; thus, X chromosome expression must be adjusted to compensate for the difference in dosage between the sexes ...
Mitzi I. Kuroda, Richard L. Kelley
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In many species, females possess two X chromosomes and males have one X chromosome. This difference is critical for the initial determination of sex. However, the X encodes many functions required equally in males and females; thus, X chromosome expression must be adjusted to compensate for the difference in dosage between the sexes ...
Mitzi I. Kuroda, Richard L. Kelley
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Current Opinion in Pediatrics, 2001
The biology of the X chromosome is unique, as there are two Xs in females and only a single X in males, whereas the autosomes are present in duplicate in both sexes. The presence of only a single autosome, which can occur as a result of an error in meiotic segregation, is invariably an embryonic lethal event.
Michael A. Goldman, Stanley M. Gartler
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The biology of the X chromosome is unique, as there are two Xs in females and only a single X in males, whereas the autosomes are present in duplicate in both sexes. The presence of only a single autosome, which can occur as a result of an error in meiotic segregation, is invariably an embryonic lethal event.
Michael A. Goldman, Stanley M. Gartler
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Annual Review of Biochemistry, 2018
X chromosome regulation represents a prime example of an epigenetic phenomenon where coordinated regulation of a whole chromosome is required. In flies, this is achieved by transcriptional upregulation of X chromosomal genes in males to equalize the gene
Maria Samata, A. Akhtar
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X chromosome regulation represents a prime example of an epigenetic phenomenon where coordinated regulation of a whole chromosome is required. In flies, this is achieved by transcriptional upregulation of X chromosomal genes in males to equalize the gene
Maria Samata, A. Akhtar
semanticscholar +1 more source
Chromosome imprinting and the mammalian X chromosome [PDF]
Nature, 1975 Chromosome imprinting is the process by which one of two genetically homologous chromosomes is predetermined to function differently from the other at a subsequent stage in development. In the coccid insects, imprinting occurs in the egg, at the time of fertilisation; it probably occurs at the same time and site in mammals, and possibly also in Sciara.
Spencer W. Brown, H. Sharat Chandra
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Pathology, 1983
Publisher Summary The fragile X chromosome is associated with a common form of X-linked mental retardation in males and possibly females. The fragile X is so called because it has a fragile site at the distal end of the long arm. Fragile sites are morphological features of chromosomes defined as specific points liable to show some specific features ...
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Publisher Summary The fragile X chromosome is associated with a common form of X-linked mental retardation in males and possibly females. The fragile X is so called because it has a fragile site at the distal end of the long arm. Fragile sites are morphological features of chromosomes defined as specific points liable to show some specific features ...
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Digging into X chromosome inactivation
Science, 2021Characterizing X chromosome inactivation in nonhuman primates reveals some ...
Rougeulle, C., Heard, Edith
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Annals of Internal Medicine, 1962
The history of our knowledge of the X chromosome of man is reviewed with appropriate reference to the contributions made through study of other forms. It is noteworthy that sex-linkage was first observed in man. X-linkage has been established for about 60 traits in man.
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The history of our knowledge of the X chromosome of man is reviewed with appropriate reference to the contributions made through study of other forms. It is noteworthy that sex-linkage was first observed in man. X-linkage has been established for about 60 traits in man.
openaire +4 more sources