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Neuroprotective Properties of Xenon [PDF]

Molecular Neurobiology, 2019
Xenon is a rare noble gas that was introduced into clinical practice more than 70 years ago. Xenon's clinical properties are predicated by its ability to fit into preformed cavities of macromolecules thereby altering their biological functions. One such action targets the NMDA-subtype of the glutamate receptors thereby inhibiting its excitatory action.
Maze, Mervyn, Laitio, Timo
openaire   +6 more sources

Interim analysis of the long‐term efficacy and safety of azetukalner in an ongoing open‐label extension study following a phase 2b clinical trial (X‐TOLE) in adults with focal epilepsy [PDF]

Epilepsia Open
Objective To report interim data from an ongoing, open‐label extension (OLE) of a Phase 2b study (X‐TOLE) of azetukalner in adults with focal onset seizures (FOS) receiving 1–3 antiseizure medications. Methods Eligible participants enrolled in the 7‐year
Jacqueline A. French, Roger J. Porter, Emilio Perucca, Martin J. Brodie, Michael A. Rogawski, Cynthia Harden, Jenny Qian, Constanza Luzon Rosenblut, Christopher Kenney, Gregory N. Beatch, X‐TOLE Study Group   +10 more
doaj   +2 more sources

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

eLife, 2022
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target NaV1.6 channels. Such a molecule provides a precision-medicine approach to target SCN8A-related epilepsy syndromes (SCN8A-RES), where gain-of-function (GoF ...
JP Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Jean-Christophe Andrez, Girish Bankar, David Bogucki, Kristen Burford, Elaine Chang, Sultan Chowdhury, Richard Dean, Gina de Boer, Shannon Decker, Christoph Dehnhardt, Mandy Feng, Wei Gong, Michael Grimwood, Abid Hasan, Angela Hussainkhel, Qi Jia, Stephanie Lee, Jenny Li, Sophia Lin, Andrea Lindgren, Verner Lofstrand, Janette Mezeyova, Rostam Namdari, Karen Nelkenbrecher, Noah Gregory Shuart, Luis Sojo, Shaoyi Sun, Matthew Taron, Matthew Waldbrook, Diana Weeratunge, Steven Wesolowski, Aaron Williams, Michael Wilson, Zhiwei Xie, Rhena Yoo, Clint Young, Alla Zenova, Wei Zhang, Alison J Cutts, Robin P Sherrington, Simon N Pimstone, Raymond Winquist, Charles J Cohen, James R Empfield   +49 more
doaj   +1 more source

Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures

Frontiers in Cellular Neuroscience, 2022
Voltage-gated sodium channels (Nav) are essential for the initiation and propagation of action potentials in neurons. Of the nine human channel subtypes, Nav1.1, Nav1.2 and Nav1.6 are prominently expressed in the adult central nervous system (CNS).
Samrat Thouta, Matthew G. Waldbrook, Sophia Lin, Arjun Mahadevan, Janette Mezeyova, Maegan Soriano, Pareesa Versi, Samuel J. Goodchild, R. Ryley Parrish, R. Ryley Parrish   +9 more
doaj   +1 more source

Xenon LFP Analysis Platform Is a Novel Graphical User Interface for Analysis of Local Field Potential From Large-Scale MEA Recordings

Frontiers in Neuroscience, 2022
High-density multi-electrode array (HD-MEA) has enabled neuronal measurements at high spatial resolution to record local field potentials (LFP), extracellular action potentials, and network-wide extracellular recording on an extended spatial scale. While
Arjun Mahadevan, Neela K. Codadu, R. Ryley Parrish   +2 more
doaj   +1 more source

Capturing seizures in clinical trials of antiseizure medications for KCNQ2‐DEE

Epilepsia Open, 2021
Literature review of patients with KCNQ2 developmental and epileptic encephalopathy (KCNQ2‐DEE) reveals, based on 16 reports including 139 patients, a clinical phenotype that includes age‐ and disease‐specific stereotyped seizures.
John J. Millichap, Cynthia L. Harden, Dennis J. Dlugos, Jacqueline A. French, Noam N. Butterfield, Celene Grayson, Ernesto Aycardi, Simon N. Pimstone   +7 more
doaj   +1 more source

Xenon

Nuclear Physics B - Proceedings Supplements, 2007
http://www.sciencedirect.com/science/article/B6TVD-4R68DXJ-12/1 ...
Aprile, E, et al, Monzani, M E, Baudis, L   +3 more
openaire   +3 more sources

Assessment of Amnesic Effect and the Depth of Hypnosis During Therapeutic Inhalation of Xenon-Oxygen Mixture

Вестник анестезиологии и реаниматологии, 2022
The current literature lacks data on the incidence of intraoperative awakening during xenon anesthesia. This could be due to amnesia preventing memories of the intraoperative awakening.The objective: to determine the concentration of xenon in the xenon ...
I. A. Lisichenko, V. G. Gusarov, B. A. Teplykh, N. V. Chayanov, M. N. Zamyatin   +4 more
doaj   +1 more source

Characteristics of Dynamic Adsorption at Ultra-Low Temperatures for Xenon

He huaxue yu fangshe huaxue, 2023
Temperature swing adsorption is one of most important means of the enrichment of xenon, and temperature is an important factor affecting adsorbent performance for xenon.
LONG Bin, ZHOU Guo-qing, FENG Shu-juan, CHEN Wei, TIAN Mei, ZHANG Yang, DU Ji-xing   +6 more
doaj   +1 more source

Can Ultrasound-Guided Xenon Delivery Provide Neuroprotection in Traumatic Brain Injury?

Neurotrauma Reports, 2022
Traumatic brain injury (TBI) is associated with high mortality and morbidity in children and adults. Unfortunately, there is no effective management for TBI in the acute setting.
Misun Hwang, Rajarshi Chattaraj, Anush Sridharan, Samuel S. Shin, Angela N. Viaene, Sophie Haddad, Dmitry Khrichenko, Chandra Sehgal, Daeyeon Lee, Todd J. Kilbaugh   +9 more
doaj   +1 more source