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An Update on Xenotransplantation
Veterinary Research Communications, 2007Xenotransplantation is one of the possible avenues currently being explored to address the shortage problem of human organs. With this in mind, this article will briefly review the current situation with respect to the immunological, physiological and biosafety aspects related to the transplantation of pig organs into primates.
COZZI E +5 more
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Zoonosis in xenotransplantation
Current Opinion in Immunology, 1998Species barriers against microbial infection will be lowered to an unprecedented degree in xenotransplantation settings. Our knowledge about micro-organisms in donor animals is limited and it is difficult to predict the consequence of such cross-species infection.
C, Patience, Y, Takeuchi, R A, Weiss
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Xenotransplantation in transition
Human Immunology, 2023The application of xenotransplantation of porcine organs and tissues for treatment of disease, sought for more than a century, might soon be realized. Until now, the immune response of recipients against xenogeneic organs and tissues posed the main obstacle to clinical application.
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The emergence of xenotransplantation
Transplant Immunology, 1995The field of transplantation is faced with a growing shortage of human organs as the list of potential recipients continues to increase. Those currently listed can already expect long waits; some die waiting. Xenotransplantation is a potential solution to this widening donor-recipient disparity.
J P, Fryer, J R, Leventhal, A J, Matas
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Xenotransplantation and tolerance
Frontiers in Bioscience, 2002Donor organ availability has become a major limiting factor in the progress of allotransplantation. This, and advances in genetic engineering in pigs, have led to increasing interest in the use of xenogeneic organs. In view of the greater difficulty encountered in overcoming immune responses to xenografts than to allografts, the success of clinical ...
Christoph, Knosalla, David K C, Cooper
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Trends in Cardiovascular Medicine, 1998
Over the past 20 years, the mortality and morbidity associated with cardiac allotransplantation has fallen significantly, providing a viable treatment for patients with terminal cardiac failure. Unfortunately, the increase in the number of patients who could benefit from cardiac transplantation has not been matched with an increase in the number of ...
A J, d'Apice, D J, Goodman, M J, Pearse
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Over the past 20 years, the mortality and morbidity associated with cardiac allotransplantation has fallen significantly, providing a viable treatment for patients with terminal cardiac failure. Unfortunately, the increase in the number of patients who could benefit from cardiac transplantation has not been matched with an increase in the number of ...
A J, d'Apice, D J, Goodman, M J, Pearse
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Current Opinion in Organ Transplantation, 2019
Purpose of review Organ transplantation is an effective treatment for selected patients with end-stage organ disease or specific cancer types. Its main limitations are the chronic lack of grafts and the lifetime need for immunosuppression.
Oldani, Graziano +2 more
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Purpose of review Organ transplantation is an effective treatment for selected patients with end-stage organ disease or specific cancer types. Its main limitations are the chronic lack of grafts and the lifetime need for immunosuppression.
Oldani, Graziano +2 more
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Progress in xenotransplantation
Expert Opinion on Investigational Drugs, 1999Organ transplantation is considered the most effective treatment for end-stage organ failure; currently it is limited by a severe worldwide shortage of human donor organs. This has led to investigation of the potential use of animals as organ donors. For a number of reasons, the pig represents the most likely organ donor candidate. Transplantation of a
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Barriers to xenotransplantation
Nature Medicine, 1995The current resurgence of interest in xenotransplantation will result in better definition of the mechanisms responsible for xenograft rejection and should facilitate appropriate therapeutic strategies to provide for long-term graft survival.
F H, Bach +6 more
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