Results 61 to 70 of about 25,299 (246)
Evidence of Oxidative Stress and Secondary Mitochondrial Dysfunction in Metabolic and Non-Metabolic Disorders [PDF]
, 2017 : Mitochondrial dysfunction and oxidative stress have been implicated in the pathogenesis of a number of diseases and conditions. Oxidative stress occurs once the antioxidant defenses of the body become overwhelmed and are no longer able to detoxify ...
Angermuller +25 more
core +1 more source
Advanced Science, Volume 13, Issue 5, 27 January 2026.This study develops a photo‐empowered macrophage‐based (PEM) drug delivery system that provides a novel and effective solution for restoring cellular motility to enhance drug delivery and overcome hypoxia‐induced multidrug resistance. The construction of the PEM system fully exploits the unique biological properties of macrophages and the energy ...
Zhaoming Fu +10 more
wiley +1 more source
Promising Results With NAD Supplementation in Rare Diseases With Premature Aging and DNA Damage
Aging Cell, Volume 25, Issue 1, January 2026.Increased DNA damage leads to increased parylation, causing mitochondrial dysfunction. This happens when DNA repair is defective, for example in known diseases and DNA repair capacity varies between individuals, some being at higher risk for hyperparylation.
Vilhelm A. Bohr
wiley +1 more source
Myrid of histopathological features of malignancy in Xeroderma pigmentosum
Journal of Pathology of Nepal, 2013 Background: Xeroderma pigmentosum is a rare autosomal recessively inherited disorder affecting 1 in 2,50,000 population. It shows genetic heterogeneity with at least ten different complementation groups identified which have different clinical ...
S Karki, G Pandey, N Bhattarai
doaj +1 more source
Case Reports in Dermatological Medicine, Volume 2026, Issue 1, 2026.Basal cell carcinoma (BCC) is a commonly occurring cutaneous malignancy predominantly affecting sun‐exposed areas. While the face and neck are typical sites, distal extremity involvement is rare. This case report presents an atypical case of nodular‐type BCC arising on the right ring finger of a 49‐year‐old male with a history of HIV infection and ...
Bhakinai Temnithikul +4 more
wiley +1 more source
PLoS ONE, 2022 Nucleotide Excision Repair is one of the five DNA repair systems. More than 30 proteins are involved in this process, including the seven XP proteins. When mutated, the genes coding for these proteins are provoking the rare disease Xeroderma Pigmentosum,
Florent Taupelet +4 more
doaj +1 more source
Indian journal of dermatology, venereology and leprologyLucero R, Horowitz D.
europepmc +2 more sources
Mouse model for the DNA repair/basal transcription disorder Trichothiodystrophy reveals cancer predisposition. [PDF]
, 1999 Patients with the nucleotide excision repair (NER) disorder xeroderma pigmentosum (XP) are highly predisposed to develop sunlight-induced skin cancer, in remarkable contrast to photosensitive NER-deficient trichothiodystrophy (TTD) patients carrying ...
Beems, R.B. (Rudolf) +12 more
core +1 more source