Results 71 to 80 of about 25,299 (246)
Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes
FEBS Letters, Volume 599, Issue 24, Page 3669-3684, December 2025.The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji +3 more
wiley +1 more source
Xeroderma Pigmentosum Variant Type, a Genodermatosis With Long‐Term Survival
JEADV Clinical Practice, EarlyView.
Perez‐Romero Ana Gabriela +2 more
wiley +1 more source
Cancer Medicine, Volume 14, Issue 24, December 2025.This article provides a comprehensive overview of basal cell carcinoma (BCC), focusing on innovative non‐surgical prevention and treatment protocols. It introduces a novel, practitioner‐friendly algorithm for BCC management, offering clear guidance for selecting treatment based on patient profiles and tumor characteristics.
Sophia Levit +2 more
wiley +1 more source
Xeroderma Pigmentosum With Early And Rapid Development Of Malignancy
Indian Journal of Dermatology, 2000 A case of xeroderma pigmentosum in a 9 year old developing multiple tumours over a short period of 6 months is reported. The tumours showed two different types of malignancies-squamous cell carcinoma and malignant melanoma.
Ghosh Arghyaprasum +2 more
doaj
Some problems and errors in cytogenetic biodosimetry [PDF]
, 2016 Human radiosensitivity is a quantitative trait that is generally subject to binomial distribution. Individual radiosensitivity, however, may deviate significantly from the mean (by 2-3 standard deviations).
Kilchevsky, Alexander +3 more
core +5 more sources
Alkaline Bromodeoxyuridine (BrdU) Comet Assay to Detect Replication‐Associated DNA Damage
Current Protocols, Volume 5, Issue 12, December 2025.Abstract DNA replication is often challenged by endogenous and exogenous sources of DNA damage, which can stall replication forks and result in single‐stranded DNA (ssDNA) gaps, double‐strand breaks (DSBs), and genomic instability. Detecting DNA damage specifically in newly synthesized DNA strands is essential for understanding how eukaryotic cells ...
Diego Luis Ribeiro +3 more
wiley +1 more source
A Novel DNA Repair Disorder With Thrombocytopenia, Nephrosis, and Features Overlapping Cockayne Syndrome [PDF]
, 2009 We report on four siblings with Cockayne-like syndrome with thrombocytopenia and nephrotic syndrome. The parents were healthy and consanguineous, consistent with an autosomal recessive mode of disease inheritance.
Cockayne +11 more
core +3 more sources
Translational Aspects of DNA Damage Repair in Optimizing Cancer Chemotherapy
Advanced Genetics, Volume 6, Issue 4, December 2025.This review systematically delineates the fundamental role and recent advancements in DNA damage response (DDR) within the context of cancer chemotherapy. Particular emphasis is directed toward exploring the interplay between DDR status and chemosensitivity.
Anqi Lin +7 more
wiley +1 more source
Xeroderma pigmentosum: A rare case report with review of literature
Journal of Indian Academy of Oral Medicine and Radiology, 2012 Xeroderma pigmentosum, or XP, is an autosomal recessive genetic disorder in which the ability to repair DNA damage caused by ultraviolet (UV) light is deficient. In extreme cases, all exposure to sunlight must be forbidden, no matter how small.
B Anand +3 more
doaj +1 more source
Ocular Surface Squamous Neoplasia in Xeroderma Pigmentosum [PDF]
, 2013 Xeroderma pigmentosum (XP) is a rare genetic disorder associated with multiple oculocutaneous and neurological manifestations. It occurs due to deficiency of the enzymes responsible for repairing ultraviolet radiation-induced DNA damage.
Ajay R Kamath +5 more
core +1 more source