Non‐Metastatic Squamous Cell Carcinoma of the Oropharynx: Primary Surgery or (Chemo)radiotherapy?
ABSTRACT Background In patients with locally advanced, non‐metastatic oropharyngeal squamous cell carcinoma (OPSCC), surgery‐based and nonsurgical treatment approaches have not been adequately compared in randomized Phase III clinical trials. Current clinical guidelines recommend various surgical and nonsurgical strategies across disease stages for ...
Primož Strojan +12 more
wiley +1 more source
Xerostomia as an oral-systemic indicator: Etiology, diagnostic strategies and multimodal management approaches. [PDF]
Parani A +5 more
europepmc +1 more source
Radiotherapy‐Induced Otitis Media With Effusion in Nasopharyngeal Carcinoma: A Meta‐Analysis
This meta‐analysis of eight studies comprising 582 NPC patients provides the first quantitative synthesis of radiotherapy‐induced otitis media with effusion (OME), demonstrating a significant overall risk difference of 0.18 (95% CI: −0.06 to 0.42, p < 0.0001) in OME naive ears.
Nevin Yi Meng Chua +3 more
wiley +1 more source
Oral dryness related symptoms in radiation-treated head and neck cancer patients: a pilot study of oral microbiome composition and function. [PDF]
Mougeot JC +5 more
europepmc +1 more source
Transoral Robotic Resection of Pediatric Tongue Base Mucoepidermoid Carcinoma
Transoral robotic surgery (TORS) offers a precise, minimally invasive approach for the management of rare pediatric tongue base malignancies. Intraoperative visualization demonstrates accurate tumor delineation and controlled resection, while postoperative findings confirm effective oncologic clearance with preservation of surrounding structures.
Krisztina Somogyvári +4 more
wiley +1 more source
Comparative Dosimetric and Radiobiological Evaluation of Dental Structures and Normal Tissue Complication Probability. [PDF]
Gulia SK +5 more
europepmc +1 more source
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen +3 more
wiley +1 more source
Relative risk of oral manifestations with celiac disease: a systematic review and meta-analysis. [PDF]
Zhao Y, Feng W.
europepmc +1 more source
ABSTRACT Objective This systematic review and meta‐analysis evaluated the relationship between nutritional status and the oral health of older adults (aged 75 years or older). The PECO focus question was, ‘What is the occurrence, association and impact of nutritional state on the oral health outcomes and its management in older adults?’ Methods A ...
Kittipit Srisanoi +8 more
wiley +1 more source
Polypharmacy, salivary function, and oral health outcomes in institutionalized older adults: A scoping review. [PDF]
Espada-Salgado FM +3 more
europepmc +1 more source

