Results 71 to 80 of about 53,688 (296)

Cancer therapy‐induced ototoxicity: Current challenges and emerging management strategies

Animal Models and Experimental Medicine, EarlyView.
This review comprehensively examines the key risk factors for cancer therapy‐induced ototoxicity, including cumulative drug dose, genetic susceptibility, and combined treatment regimens. It highlights current challenges in ototoxicity monitoring, such as insufficient timeliness and limited clinical adoption, and advocates for standardized auditory ...
Yuqi Huang, Baoying Xu, Xinru Chen, Yu Chen, Dehong Yu   +4 more
wiley   +1 more source

Impact of Oral Cavity Dosimetry on Patient Reported Xerostomia and Dysgeusia in the Setting of Deintensified Chemoradiotherapy

Advances in Radiation Oncology, 2022
Purpose: To determine the relationship between mean oral cavity (OC) dose (treated as a singular organ at risk) to patient reported xerostomia and dysgeusia.
David V. Fried, PhD, Shiva K. Das, PhD, Colette Shen, MD, PhD, Lawrence B. Marks, MD, Bhishamjit S. Chera, MD   +4 more
doaj   +1 more source

Staff-led interventions for improving oral hygiene in patients following stroke [PDF]

, 2010
Background For people with limitations due to neurological conditions such as stroke, the routine practice of oral care may become a challenge. Evidence-based supported oral care intervention is essential for this patient group. Objectives To compare the
Brady, Marian C., Furlanetto, Denise, Hunter, Romana, Lewis, Steff C., Milne, Vikki   +4 more
core   +3 more sources

Clock genes regulate Ca2+ signaling and mitochondrial bioenergetics to inhibit Sjogren's disease

Arthritis &Rheumatology, Accepted Article.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjogren's disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA seq, and mitochondrial activity were used to investigate the effects of ...
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento Da Conceicao, Neelanjan Vishnu, Shankara N Varadarajan, Venugopal R. Bovilla, Rajender K Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

NTCP modeling and dose–volume correlations for acute xerostomia and dry eye after whole brain radiation

Radiation Oncology, 2021
Background Whole brain radiation (WBRT) may lead to acute xerostomia and dry eye from incidental parotid and lacrimal exposure, respectively. We performed a prospective observational study to assess the incidence/severity of this toxicity.
Panayiotis Mavroidis, Kevin A. Pearlstein, Dominic H. Moon, Victoria Xu, Trevor J. Royce, Ashley A. Weiner, Colette J. Shen, Lawrence B. Marks, Bhishamjit S. Chera, Shiva K. Das, Kyle Wang   +10 more
doaj   +1 more source

NASA Light-Emitting Diodes for the Prevention of Oral Mucositis in Pediatric Bone Marrow Transplant Patients [PDF]

, 2002
Objective: The purpose of this study was to determine the effects of prophylactic near-infrared light therapy from light-emitting diodes (LEDs) in pediatric bone marrow transplant (BMT) recipients.
Barbeau, Lori, Buchmann, Ellen V., Bullard, George, Connelly, James F., Hodgson, Brian D., Kane, Mary, Margolis, David, Post, A. Charles, Warwick, Ann, Whelan, Harry T., Whelan, Noel T.   +10 more
core   +1 more source

Validation of smart nanoparticles as controlled drug delivery systems: loading and pH-dependent release of pilocarpine [PDF]

, 2017
Micelles are good devices for use as controlled drug delivery systems because they exhibit the ability to protect the encapsulated substance from the routes of degradation until they reach the site of action. The present work assesses loading kinetics of
Galbis Fuster, Elsa, Iglesias González, Nieves, Lucas Rodríguez, Ricardo, Muñoz Guerra, Sebastián, Tinajero, Ernesto   +4 more
core   +2 more sources

How Would You Treat? A Case‐Vignette Study of Provider Treatment Preferences in Human Papillomavirus‐Mediated Oropharyngeal Cancer

Head &Neck, EarlyView.
ABSTRACT Background Current guidelines recommend surgical resection, definitive radiotherapy (RT), or concurrent chemoradiotherapy (CRT) for human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma (OPSCC). This study aimed to provide insight into practice patterns of providers who treat HPV‐associated OPSCC.
Sindhura Sridhar, Michael R. Papazian, Michael C. Topf   +2 more
wiley   +1 more source

Risk factors for chest infection in acute stroke: a prospective cohort study [PDF]

, 2007
<p><b>Background and Purpose:</b> Pneumonia is a major cause of morbidity and mortality after stroke. We aimed to determine key characteristics that would allow prediction of those patients who are at highest risk for poststroke ...
Bagg, J., Bowie, L., Langhorne, P., Miller, H., Sellars, C., Stott, D.J., Sweeney, M.P., Tilston, J.   +7 more
core   +1 more source

Intraoperative Indocyanine Green Fluorescence Enables Primary Tumor Localization and Treatment De‐Escalation in SCCUP: A Case Report

Head &Neck, EarlyView.
ABSTRACT Background Unknown primary cancer in the head and neck presents a difficult surgical treatment dilemma. Patients with squamous cell carcinoma of unknown primary (SCCUP) typically present with an enlarging neck mass found on biopsy but with no indication of primary site on diagnostic exams such as flexible laryngoscopy, CT, MRI, and/or PET/CT ...
Nikhil Bellamkonda, Nitish Khurana, Eric Babajanian, Hamidreza Ghandehari, Jeremiah A. Alt, Richard B. Cannon   +5 more
wiley   +1 more source