Liver stiffness in patients with Shwachman‐Diamond syndrome
Abstract Objective This case series aims to describe whether transient elastography (TE) as a marker of liver stiffness is associated with clinically important liver disease in children and young adults with Shwachman‐Diamond Syndrome (SDS). Methods All patients ≤25 years of age with genetically confirmed SDS seen in the Pediatric Gastroenterology ...
Sabina Sabharwal +5 more
wiley +1 more source
Reachable Workspace and Proximal Function Measures for Quantifying Upper Limb Motion. [PDF]
There are a lack of quantitative measures for clinically assessing upper limb function. Conventional biomechanical performance measures are restricted to specialist labs due to hardware cost and complexity, while the resulting measurements require ...
Bajcsy, Ruzena +6 more
core
Spag17 Deficiency Results in Skeletal Malformations and Bone Abnormalities [PDF]
Height is the result of many growth and development processes. Most of the genes associated with height are known to play a role in skeletal development. Single-nucleotide polymorphisms in the SPAG17 gene have been associated with human height.
Boyan, Barbara` D. +11 more
core +4 more sources
ABSTRACT Clinical islet transplantation has long been investigated as a potential cure for type 1 diabetes (T1D), yet standard intrahepatic delivery leaves islets prone to an instant blood‐mediated inflammatory response. Herein, we investigated the design of microporous poly(D,l‐lactide‐co‐glycolide) (PLG) scaffolds for extrahepatic islet ...
Jessica L. King +15 more
wiley +1 more source
Implantation of a poly-L-lactide GCSF-functionalized scaffold in a model of chronic myocardial infarction [PDF]
A previously developed poly-l-lactide scaffold releasing granulocyte colony-stimulating factor (PLLA/GCSF) was tested in a rabbit chronic model of myocardial infarction (MI) as a ventricular patch.
Chello, Massimo +10 more
core +1 more source
This study addresses a critical clinical challenge: the management of symptomatic pseudomeningocele (PMC) causing spinal cord compression following spinal surgery. Traditional treatments face limitations in efficacy and invasiveness. Here, we propose an innovative minimally invasive technique using central venous catheterization under ultrasound ...
Chen Chen +7 more
wiley +1 more source
Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome [PDF]
MRF4 (herculin/Myf-6) is one of the four member MyoD family of transcription factors identified by their ability to enforce skeletal muscle differentiation upon a wide variety of nonmuscle cell types.
Miner, Jeffrey H. +5 more
core
New information on the anatomy of the Chinese Early Cretaceous Bohaiornithidae (Aves: Enantiornithes) from a subadult specimen of Zhouornis hani [PDF]
Enantiornithines are the most diverse avian clade in the Cretaceous. However, morphological specializations indicative of specific ecological roles are not well known for this clade. Here we report on an exquisitely well-preserved specimen from the Lower
Jingmai O’Connor +5 more
core +1 more source
Prolonged survival in a young Dobermann with adrenal neuroblastoma
Abstract A 1‐year‐old Dobermann presented with recurrent episodes of acute diarrhoea and weight loss starting at 5 months of age. An adrenal mass was identified via ultrasound and computed tomography, leading to adrenalectomy. A diagnosis of adrenal neuroblastoma was obtained through histopathology and immunohistochemistry.
Nataliia Ignatenko +8 more
wiley +1 more source
Establishment of a biosafe murine model of skeletal tuberculosis using Mycobacterium smegmatis
This study developed a biosafe, accessible, and versatile murine model of bone TB using Mycobacterium smegmatis, a fast‐growing, nonpathogenic mycobacterial species with high genomic homology to Mycobacterium tuberculosis. Three infection routes—subperiosteal calvarial injection, intratibial injection, and intracardiac (left ventricular) inoculation ...
Yewei Jia +12 more
wiley +1 more source

