Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source
XML-based XML schema access [PDF]
Proceedings of the 16th international conference on World Wide Web, 2007 XML Schema's abstract data model consists of components, which are the structures that eventually define a schema as a whole. XML Schema's XML syntax, on the other hand, is not a direct representation of the schema components, and it proves to be surprisingly hard to derive a schema's components from the XML syntax. The Schema Component XML Syntax (SCX)
Erik Wilde, Felix Michel
openaire +1 more source
Integrated Development of Agricultural Machinery and Agronomy in the Hilly and Mountainous Regions of Southern China [PDF]
中国工程科学The hilly and mountainous regions of southern China are important agricultural production regions. However, the traditional agricultural model faces challenges such as low efficiency and sustainable development owing to terrain fragmentation, ecological ...
Ming Li +8 more
doaj +1 more source
Value Realization of Carbon Sink Ecological Products: Theoretical Foundation and Practice Paths [PDF]
中国工程科学The value realization of carbon sink ecological products is a vital component of the broader ecological product value realization system. Its theoretical elaboration and practical exploration are of great significance to synergistically advance ...
Yanan Ren +4 more
doaj +1 more source
Ethical Risk Identification, Governance, and Foresight of Medical Foundation Models [PDF]
中国工程科学The medical field is undergoing an intelligent transformation characterized by the emergence of multimodal foundation models. While technological empowerment brings unprecedented opportunities, it is accompanied by profound ethical risks.
Liu Liu +9 more
doaj +1 more source
Industrialized Development of Urban Photovoltaic Buildings [PDF]
中国工程科学Photovoltaic (PV) buildings generate electricity through their surfaces, which can reduce carbon emissions during operation by over 30%. The urban PV building industry in China has vast potentials for development.
Chenqi Li, Ye Cao, Xiang Li, Wen Ling
doaj +1 more source
Associating protein residues in the literature with structural data. [PDF]
Acta Crystallogr D Struct BiolA software tool is introduced for associating text mentions of protein residues with their respective residues in a protein structure, with display in a molecular viewer.Protein structures are crucial in understanding the function, mechanism and disease‐causing variants of proteins within any living cell.
Vollmar M +6 more
europepmc +2 more sources
A Precision Adaptation Resilience-Planning Methodology that Integrates Regions and Cities [PDF]
中国工程科学Safety resilience is the premise of urban construction, and creating a safety resilience planning methodology with multi-scale linkage is of great scientific significance for enhancing the overall resilience of cities and promoting high-quality urban ...
Kai Wang +7 more
doaj +1 more source
Localized Carbon Footprint Accounting Products in China: Taking the Lithium Battery Industry as an Example [PDF]
中国工程科学Establishing a localized carbon footprint accounting system for products in China is crucial for fostering new productive forces and enhancing the international competitiveness of the country. This study aims to address current challenges faced by carbon
Hanbo Gao +10 more
doaj +1 more source
A Review of China's Nickel, Cobalt, Lithium, and Vanadium Industry Chain: Current Status, Challenges, and Prospects [PDF]
中国工程科学Nickel, cobalt, lithium, and vanadium are critical minerals underpinning China's new energy industry. However, they currently face triple challenges: resource shortages, poor natural endowments, and technological bottlenecks in high-value utilization. To
Zhengchang Shen +11 more
doaj +1 more source