Results 41 to 50 of about 1,109 (182)

TRIM25 and its emerging RNA‐binding roles in antiviral defense

WIREs RNA, Volume 11, Issue 4, July/August 2020., 2020
E3 ubiquitin ligase TRIM25 is newly identified RNA‐binding protein which is emerging as a key factor in the innate immune response to RNA viruses. Abstract The innate immune system is the body's first line of defense against viruses, with pattern recognition receptors (PRRs) recognizing molecules unique to viruses and triggering the expression of ...
Nila Roy Choudhury, Gregory Heikel, Gracjan Michlewski   +2 more
wiley   +1 more source

Recombinant Origin of the Retrovirus XMRV [PDF]

Science, 2011
Analysis of the origin of XMRV suggests that links between the virus and human disease are due to laboratory contamination.
Oya Cingöz, Tobias Paprotka, Hsing Jien Kung, Matthew J. Fivash, Vinay K. Pathak, Krista A. Delviks-Frankenberry, John M. Coffin, Anthony Martinez, Clifford G. Tepper, Wei Shau Hu   +9 more
openaire   +3 more sources

XMRV infection in human diseases [PDF]

Retrovirology, 2011
The novel gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV) was identified in human prostate cancer tissue in 2006, confirmed in 2009 and later linked to a second human condition chronic fatigue syndrome, CFS. These investigations, all carried out in the US, have not been reproduced in Europe or in China. We found no evidence for
Wun-Jae Kim, Otto Erlwein, Mongkol Uiprasertkul, Marjorie M. Walker, Kikkeri N. Naresh, Anup Patel, Takahiro Kimura, Myra O. McClure, Mark J. Robinson, Steve Kaye, Ganesh Gopalakrishnan   +10 more
openaire   +3 more sources

XMRV: A New Virus in Prostate Cancer? [PDF]

Cancer Research, 2010
Abstract Several recent articles have reported the presence of a gammaretrovirus, termed “XMRV” (xenotropic murine leukemia virus-related virus) in prostate cancers (PCa). If confirmed, this could have enormous implications for the detection, prevention, and treatment of PCa.
Aloia, A., Sfanos, K., Isaacs, W., Zheng, Q., Maldarelli, F., De Marzo, A., Rein, A.   +6 more
openaire   +3 more sources

Utilization of replication-competent XMRV reporter-viruses reveals severe viral restriction in primary human cells. [PDF]

PLoS ONE, 2013
The gammaretrovirus termed xenotropic murine leukemia virus-related virus (XMRV) was described to be isolated from prostate cancer tissue biopsies and from blood of patients suffering from chronic fatigue syndrome.
Christina Martina Stürzel, David Palesch, Mohammad Khalid, Silke Wissing, Nicole Fischer, Jan Münch   +5 more
doaj   +1 more source

XMRV: Not a Mousy Virus

Journal of the Formosan Medical Association, 2011
The newly discovered mouse-derived human retrovirus, xenotropic murine leukemia virusrelated virus (XMRV), is currently fuelling both the scientific and public debate, where skeptics suggest that results are based on laboratory contamination, while the “believers” have already dressed the virus with highly pathogenic potential.
Ben Berkhout, Antoinette C. van der Kuyl
openaire   +4 more sources

Cell line tropism and replication of XMRV [PDF]

Retrovirology, 2011
Background XMRV is a gammaretrovirus closely related to xenotropic murine leukemia viruses (MuLVs). XMRV was first identified in familial cases of prostate cancer tissue using a virus gene array. Although, initial reports have identified XMRV predominantly in the prostate, recent reports of detection of XMRV in blood cells of patients with Chronic ...
Durga Gaddam, Mohan Kumar Haleyur Giri Setty, Veeraswamy Ravichandran, Shixing Tang, Jiangqin Zhao, Indira Hewlett, Xue Wang, Ragupathy Viswanath, Owen Wood, Krishnakumar Devadas, Sherwin Lee   +10 more
openaire   +3 more sources

Membrane fusion and cell entry of XMRV are pH-independent and modulated by the envelope glycoprotein's cytoplasmic tail. [PDF]

PLoS ONE, 2012
Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus that was originally identified from human prostate cancer patients and subsequently linked to chronic fatigue syndrome.
Marceline Côté, Yi-Min Zheng, Shan-Lu Liu   +2 more
doaj   +1 more source

Apobec 3G efficiently reduces infectivity of the human exogenous gammaretrovirus XMRV. [PDF]

PLoS ONE, 2010
BackgroundThe human exogenous gammaretrovirus XMRV is thought to be implicated in prostate cancer and chronic fatigue syndrome. Besides pressing epidemiologic questions, the elucidation of the tissue and cell tropism of the virus, as well as its ...
Kristin Stieler, Nicole Fischer
doaj   +1 more source

No association of xenotropic murine leukemia virus-related viruses with prostate cancer. [PDF]

PLoS ONE, 2011
BACKGROUND: The association of the xenotropic murine leukemia virus-related virus (XMRV) with prostate cancer continues to receive heightened attention as studies report discrepant XMRV prevalences ranging from zero up to 23%.
William M Switzer, Hongwei Jia, Haoqiang Zheng, Shaohua Tang, Walid Heneine   +4 more
doaj   +1 more source