Results 51 to 60 of about 2,300 (209)

TRIM25 and its emerging RNA‐binding roles in antiviral defense

WIREs RNA, Volume 11, Issue 4, July/August 2020., 2020
E3 ubiquitin ligase TRIM25 is newly identified RNA‐binding protein which is emerging as a key factor in the innate immune response to RNA viruses. Abstract The innate immune system is the body's first line of defense against viruses, with pattern recognition receptors (PRRs) recognizing molecules unique to viruses and triggering the expression of ...
Nila Roy Choudhury, Gregory Heikel, Gracjan Michlewski   +2 more
wiley   +1 more source

Crystal structure of xenotropic murine leukaemia virus-related virus (XMRV) ribonuclease H [PDF]

, 2014
RNase H (retroviral ribonuclease H) cleaves the phosphate backbone of the RNA template within an RNA/DNA hybrid to complete the synthesis of double-stranded viral DNA.
Chung, Bong Hyun, Chung, Sang J., Erikson, Raymond Leo, Jung, Suk-Kyeong, Kang, Sunghyun, Kim, Bo Yeon, Kim, Ju Hee, Kim, Seung Jun, Yu, Keum Ran   +8 more
core   +1 more source

XMRV and prostate cancer—a 'final' perspective [PDF]

Nature Reviews Urology, 2012
XMRV was first described in 2006, when it was identified in samples isolated from prostate cancer tissues. However, studies have since shown that XMRV arose in the laboratory and was formed by genetic recombination between two viral genomes carried in the germline DNA of mice used during serial transplantation of the CWR22 prostate cancer xenograft ...
Sfanos, K.S., Aloia, A.L., De Marzo, A.M., Rein, A.   +3 more
openaire   +3 more sources

XMRV: Not a Mousy Virus

Journal of the Formosan Medical Association, 2011
The newly discovered mouse-derived human retrovirus, xenotropic murine leukemia virusrelated virus (XMRV), is currently fuelling both the scientific and public debate, where skeptics suggest that results are based on laboratory contamination, while the “believers” have already dressed the virus with highly pathogenic potential.
van der Kuyl, Antoinette C., Berkhout, Ben   +1 more
openaire   +4 more sources

Absence of detectable XMRV and other MLV-related viruses in healthy blood donors in the United States. [PDF]

PLoS ONE, 2011
BACKGROUND: Preliminary studies in chronic fatigue syndrome (CFS) patients and XMRV infected animals demonstrated plasma viremia and infection of blood cells with XMRV, indicating the potential risk for transfusion transmission.
Shixing Tang, Jiangqin Zhao, Mohan Kumar Haleyur Giri Setty, Krishnakumar Devadas, Durga Gaddam, Ragupathy Viswanath, Owen Wood, Panhe Zhang, Indira K Hewlett   +8 more
doaj   +1 more source

XMRV infection in human diseases [PDF]

Retrovirology, 2011
The novel gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV) was identified in human prostate cancer tissue in 2006, confirmed in 2009 and later linked to a second human condition chronic fatigue syndrome, CFS. These investigations, all carried out in the US, have not been reproduced in Europe or in China. We found no evidence for
Kimura Takahiro, Gopalakrishnan Ganesh, Uiprasertkul Mongkol, Kim Wun-Jae, Patel Anup, Walker Marjorie M, McClure Myra O, Kaye Steve, Robinson Mark J, Erlwein Otto, Naresh Kikkeri   +10 more
openaire   +2 more sources

The gammaretroviral p12 protein has multiple domains that function during the early stages of replication. [PDF]

, 2012
BACKGROUND: The Moloney murine leukaemia virus (Mo-MLV) gag gene encodes three main structural proteins, matrix, capsid and nucleocapsid and a protein called p12.
Allen, David J, Bishop, Kate N, Boucherit, Virginie C, Nader, Mirella, Taylor, Ian A, Wight, Darren J   +5 more
core   +2 more sources

Complex Codon Usage Pattern and Compositional Features of Retroviruses

Computational and Mathematical Methods in Medicine, Volume 2013, Issue 1, 2013., 2013
Retroviruses infect a wide range of organisms including humans. Among them, HIV‐1, which causes AIDS, has now become a major threat for world health. Some of these viruses are also potential gene transfer vectors. In this study, the patterns of synonymous codon usage in retroviruses have been studied through multivariate statistical methods on ORFs ...
Sourav RoyChoudhury, Debaprasad Mukherjee, Kazuhisa Nishizawa   +2 more
wiley   +1 more source

A Role for the Intestinal Microbiota and Virome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)? [PDF]

, 2016
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a heterogeneous disorder of significant societal impact that is proposed to involve both host and environmentally derived aetiologies that may be autoimmune in nature. Immune-related symptoms
Acheson, Bassi, Burbelo, Caligiuri, Carlo-Stella, Collins, Enbom, Fattah, Fremont, Gill, Jason, Klein, Klimas, Kumar, Lerner, Lerner, Maes, Meeus, Nishikai, Sharpe, Sheedy, Tannock, Vollmer-Conna   +22 more
core   +2 more sources

Toxoplasmosis and Polygenic Disease Susceptibility Genes: Extensive Toxoplasma gondii Host/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders

Journal of Pathogens, Volume 2013, Issue 1, 2013., 2013
Toxoplasma gondii is not only implicated in schizophrenia and related disorders, but also in Alzheimer′s or Parkinson′s disease, cancer, cardiac myopathies, and autoimmune disorders. During its life cycle, the pathogen interacts with ~3000 host genes or proteins.
C. J. Carter, Cormac G. M. Gahan
wiley   +1 more source