Results 191 to 199 of about 144,082 (199)

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Chromosomal rearrangements: tempo and mode of karyotype evolution in Scarabaeoidea. [PDF]

J Evol Biol
Chien S, Blackmon H.
europepmc   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

PEG-rhGH successfully improved the height of a patient with rare 45,X[40]/46,XY[31] disorder of sex development: the first reported case. [PDF]

Transl Pediatr
Li S, Ge R, Liao N, Su Y, Lei C, Hu S, Wang Y, Ren Y.   +7 more
europepmc   +1 more source

Gate-Tunable Remnant Anomalous Hall Effect in Dual-‍Proximity Graphene Heterostructures. [PDF]

Small Sci
Satheesh S, Bernard A, Naimer T, Knöckl E, Taniguchi T, Watanabe K, Fabian J, Holleitner A, Kastl C, Burghard M.   +9 more
europepmc   +1 more source

Molecular Characterization and Functional Analysis of <i>Amhr2</i> in Sex Differentiation and Gonadal Development of Blotched Snakehead (<i>Channa maculata</i>). [PDF]

Int J Mol Sci
Qin J, Zhang Y, Shi J, Luo Q, Liu H, Fei S, Zhang X, Sun Y, Zhao J, Ou M.   +9 more
europepmc   +1 more source

The Association Between Potential Nuclear Factor-Kappa B1 Gene Polymorphism rs28362491 and miR-206 Level in Patients With Acute Lymphoblastic Leukemia. [PDF]

World J Oncol
Muradi I, Alhmoud J, Al-Qaraleh M, Sughayer M, Halahleh K.   +4 more
europepmc   +1 more source

DAXX directs dual modes of H3.4-to-H3.3 histone replacement in the male germline. [PDF]

Genes Dev
Yeh YH, Hu M, Otsuka K, Alger BM, Nene SS, Wang H, Maezawa S, Namekawa SH.   +7 more
europepmc   +1 more source

Desert Hedgehog mediates stem Leydig cell differentiation through Ptch2/Gli1/Sf1 signaling axis. [PDF]

Elife
Zhao C, Chen Y, Liu L, Liu X, Xiao H, Wang F, Huang Q, Dai X, Tao W, Wang D, Wei J.   +10 more
europepmc   +1 more source