Results 171 to 180 of about 287,328 (301)

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Royal jelly ameliorates behavioral deficit and hippocampal damage induced by inhalation exposure to xylene. [PDF]

Sci Rep
Khazaeel K, Sadeghi A, Hussein HA, Hosseinifar S, Ezzati-Givi M, Ghotbeddin Z, Jahangiri R, Alizamani F, Makipour A.   +8 more
europepmc   +1 more source

Chemically Engineered L. reuteri Delivering αPD‐L1 and Gallium Ions via Metal‐Phenolic Networks Potentiate Anti‐Tumor Immunity and Ferroptosis

Advanced Science, EarlyView.
A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang, Mengyi Xu, Yan Zhang, Zhiwen Li, Danqing Song, Jing Pang, Ke Li, Yanxiang Wang   +7 more
wiley   +1 more source

Determination of Eight Benzene Homologs in Ambient Air and Indoor Air in Residential Areas by Secondary Thermal Desorption-Gas Chromatography. [PDF]

Int J Anal Chem
Liu T, Yuan X, Yang T, Yang C, Zhao H, Jiang J, Feng J.   +6 more
europepmc   +1 more source

Chemical compounds of the foraging recruitment pheromone in bumblebees [PDF]

, 2005
Chittka, L, Dornhaus, A, Ghani, J, Gonzalez, FJE, Granero, AM, Sanz, JMG, Serrano, AR, Vidal, JLM   +7 more
core   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Organized and Fugitive VOC Emissions from Typical Industrial Parks and Their Impact on Secondary Pollution. [PDF]

Toxics
Liu T, Li X, Wu W, Yan M, He Y, Quan X, Liu P, Xu H, Shen Z.   +8 more
europepmc   +1 more source

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

From rice-husk waste to selective BTEX adsorbents: modified MWCNTs reveal a co-adsorption swing effect and improve field monitoring. [PDF]

RSC Adv
Le AHQ, Hoang HY.
europepmc   +1 more source

Quantitative Analysis of Xylene Mixtures Using a Handheld Raman Spectrometer [PDF]

, 2019
Reilly, Lauren
core   +1 more source