Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu +13 more
wiley +1 more source
Determining molecular structure, coordination geometry, and molecular symmetry using a continuous symmetry operation measure software. [PDF]
Nielsen VRM, Just Sørensen T.
europepmc +1 more source
A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals
This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao +16 more
wiley +1 more source
Enantioselective Synthesis of α-Oxygenated Ketones via Organocatalytic Formal O-H Bond Insertion of Sulfonium Ylides. [PDF]
Qian C +5 more
europepmc +1 more source
Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu +8 more
wiley +1 more source
Ethylbenzene Exposure and Bronchoalveolar CD4/CD8 T Cells in Hypersensitivity Pneumonitis Development and Clinical Outcome. [PDF]
Minguela A +16 more
europepmc +1 more source
By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang +27 more
wiley +1 more source
Catalytic Enantioselective Synthesis of Oxazolines with Vinylogous Isocyano Esters. [PDF]
Guzmán-Cedillo C +4 more
europepmc +1 more source
GSK3β‐Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy
Uterine Gsk3b knockout impairs decidual cell terminal differentiation by causing lipid droplet accumulation. GSK3β phosphorylates RNF213 to promote its lysosomal degradation, thereby enhancing lipolysis. The released fatty acids undergo β‐oxidation to generate acetyl‐CoA, which modulates histone acetylation and regulates decidual cell terminal ...
Peiran Wang +14 more
wiley +1 more source
Interfacial Properties of Miktoarm Star Polymers with a Poly(divinylbenzene) Core. [PDF]
Lin TC +5 more
europepmc +1 more source

