Results 91 to 100 of about 11,512 (298)

Economic evaluation of aromatics production, a case study for financial model application in petrochemical projects

Egyptian Journal of Petroleum, 2017
Economics is the engine that drives industry. For complete understanding of project economics four major items must be discussed; capital requirements, operating expenses, cash flow and profitability measures.
H.R. Omran, S.M. EL-Marsafy, F.H. Ashour, E.F. Abadir   +3 more
doaj   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Control del Formaldehído, Xileno y Compuestos Orgánicos Volátiles mediante el Sistema Integral de Friocongelación y Fotocatalización

Medicina y Seguridad del Trabajo
RESUMEN Antecedentes: En anatomía patológica, existen variedad de agentes químicos que deben ser controlados. Por su potencial cancerígeno destacan el Formaldehído (CH2O), Xileno y los Compuestos Orgánicos Volátiles (COVs).
Mileida Andreina Peñalver Paolini, Luis Carlos Mazón Cuadrado, Pilar Berrocal Fernández   +2 more
doaj  

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Degradação de BTXs via processos oxidativos avançados Degradation of BTXs by advanced oxidative processes

Química Nova, 2005
In this study the efficiency of advanced oxidative processes (AOPs) were investigated toward the degradation of aqueous solutions containing benzene, toluene and xylenes (BTX).
Elaine Regina Lopes Tiburtius, Patricio Peralta-Zamora, Alexandre Emmel, Elenise Sauer Leal   +3 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

All valence electron molecular orbital study of electronic strture and spectra of the three isometric xylenes

, 1972
The modified method of Del Bene and Jaffe'(CNDO-CI) has been applied to study the electronic structure and spectra of the three isomeric xylenes taking a three dimensional geometry for the CH3 group. The spectral transition energies and the corresponding
Mishra, P. G., Yadav, J. S., Rai, D. K.
core   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Occupational exposure to benzene, toluene, ethylbenzene and xylenes (BTEX), between 2015 and 2020 [PDF]

, 2021
A exposição profissional a benzeno, tolueno, etilbenzeno e xilenos (BTEX) tem efeitos nocivos para saúde (tóxicos para o sistema nervoso central e reprodução, cancerígenos, mutagénicos), que levaram a União Europeia e Portugal a estabelecer valores ...
Faria, Tiago, Pinhal, Hermínia, Pais, Aida, Nogueira, Ana, Pires, Ana Filipa, Oliveira, Anabela, Amado, Joana, Santos, Sílvia   +7 more
core