Results 271 to 280 of about 33,310 (337)

Abstract 1024 Generation of Human Metabolite Piceatannol from Resveratrol by Bacterial Toluene o-Xylene Monooxygenase Variants

Noella Younan, Eli Frazer, Felice A. Dacpano, Areli Tlatelpa, Gonul Schara   +4 more
openalex   +2 more sources

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Generation of Mono- and Bisazabicyclic <i>o</i>-Quinodimethanes through Polarity-Matched and -Mismatched 6π-Azaelectrocyclization: Access to Substituted Naphthalenes. [PDF]

Org Lett
Lee DJ, Shankar M, Acharya A, Giri R.
europepmc   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Intercalant Aggregation Promotes Nanoscopic Depletion in Droplet Interface Bilayers. [PDF]

J Phys Chem B
Scott C, Osaki T, Takeuchi S, Lee S.
europepmc   +1 more source

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, EarlyView.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source

AI‐Driven Acceleration of Fluorescence Probe Discovery

Advanced Science, EarlyView.
We present PROBY, an AI model trained on large‐scale datasets to predict key photophysical properties and accelerate the discovery of target‐specific fluorescent probes. By screening a target‐annotated library, PROBY identifies candidate probes for diverse targets and could guide probe optimization, enabling a range of in vitro and in vivo imaging ...
Xuefeng Jiang, Yanbo Li, Xue Tian, Sen Yang, Ruina Luo, Cenxing Zhou, Yuxuan Liu, Jingying Hu, Sen Feng, Lu Gan, Chongzhao Ran, Kun‐Hsing Yu, Junhan Zhao, Xiao Han, Xuan Zhai, Yuntao Jia, Jiapei Dai, Xiyue Wang, Biyue Zhu   +18 more
wiley   +1 more source

Improving Methodologies for Cumulative Risk Assessment: A Case Study of Noncarcinogenic Health Risks from Volatile Organic Compounds in Fenceline Communities in Southeastern Pennsylvania. [PDF]

Environ Health Perspect
Chiger AA, Gigot C, Robinson ES, Tehrani MW, Claflin M, Fortner E, Stark H, Krechmer J, Canagaratna MR, Herndon S, Yacovitch TI, Koehler K, Rule AM, Burke TA, Fox MA, DeCarlo PF, Nachman KE.   +16 more
europepmc   +1 more source

Contribution of biomass and biofuel emissions to trace gas distributions in Asia during the TRACE-P experiment [PDF]

, 2003
Blake, DR, Carmichael, GR, Fried, A, Fu, QY, Kurata, G, Lee, WC, Pinnock, S, Sachse, GW, Streets, DG, Tang, YH, Thongboonchoo, N, Thornton, DC, Uno, I, Vay, S, Woo, JH, Yoo, B   +15 more
core  

Highly Porous Hydrophobic Chitin-Based Carbon Foam Spheres for Gaseous Para-Xylene Removal: Preparation, Adsorption Mechanisms And Optimization

Yongjin Wang, Lei Sun, Shungang Wan, Siqin Yi, Dan Yuan, Jiangli Wu   +5 more
openalex   +1 more source