Results 21 to 30 of about 7,279 (249)

Alterações nucleares das cellulas do figado nas infecções de Macacus Rhesus e M. Cynomolgus pelo virus da febre amarella

Memorias do Instituto Oswaldo Cruz, 1928
No figado de um Macacus rhesus inoculado por BEAUREPAIRE ARAGÃO com sangue deum caso benigno de febre amarella e no qual elle descreveu symptomas e lesões typicas semelhantes ás obidas por STOKES, BAUER e HUDSON pela inoculação com o virus africano no ...
C. Magarinos Torres
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

OBTENÇÃO E CARACTERIZAÇÃO DE MATERIAL HÍBRIDO ENTRE SÍLICA E CICLODEXTRINAS

Química Nova, 2015
The obtention of silica and cyclodextrin hybrid materials was accomplished by refluxing them in xylol using citric acid as a binding agent. The materials were characterized by infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning
Raphaela V. Baracho, Lucas B. Carvalho, Jéssica M. Andrade, Adneia F. A. Venceslau, Denise A. Rocha, Luciana M. A. Pinto   +5 more
doaj   +1 more source

The Effect of Probiotic Dietary Supplementation on Ethanol-Induced White and Grey Matter Damage to the Brain in Male Wistar Rats

طب انتظامی, 2022
INTRODUCTION Ethanol is a very strong pro-oxidant that causes cellular oxidative damage, and most of its dangerous effects are attributed to acetaldehyde [1]. ... [2, 3]. Alcohol addiction is usually one of the most challenging cases that traffic police
Hadis Soleimani, Aliakbar Malekirad, Hamid Reza Mohajerani , Parvaneh Jafari1, Neda Akbari   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

DANGEROUSNESS OF CHEMICAL PRODUCTS AND WASTE FROM HOSPITAL CARE

Cogitare Enfermagem, 2012
This descriptive study aimed to identify the dangerousness attributable to chemical products and waste resulting from hospital care. The institution serving as field of study was the University Hospital of the University of São Paulo; information was ...
Taiza Florêncio Costa, Vanda Elisa Andres Felli   +1 more
doaj   +1 more source

Nanotechnology in ligature-induced periodontitis: protective effect of a doxycycline gel with nanoparticules

Journal of Applied Oral Science, 2010
OBJECTIVES: The aim of this study was to test the efficacy of a locally applied 8.5% nanostructured doxycycline (DOX) gel in preventing alveolar bone loss in experimental periodontal disease (EPD) in rats by using the tapping mode atomic force microscopy
Marco Antonio Botelho, Jose Galberto Martins, Ronaldo Sousa Ruela, Dinalva Brito Queiroz, Wagner Sousa Ruela   +4 more
doaj   +1 more source

Morphology and anatomic-surgical segmentation of the spleen of Pecari tajacu Linnaeus, 1758

Bioscience Journal, 2018
The spleen is a secondary lymphoid organ with importance in clinical surgery. Due this and the lack of data in the literature, the current paper analyzes the organ´s morphology and segmentation in collared peccaries.
Gleidson Benevides de Oliveira, Felipe Venceslau Câmara, Ferdinando Vinícius Fernandes Bezerra, Hélio Noberto de Araújo Júnior, Radan Elvis Matias de Oliveira, Herson da Silva Costa, Amilton Cesar Santos, Carlos Eduardo Bezerra de Moura, Moacir Franco de Oliveira   +8 more
doaj   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source