Results 161 to 170 of about 102,889 (306)

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source

yap

, 1956
yapCorruption of yap: noise, talk. "Not a _yap_ out of you, now!"PRINTED ITEMG.M.

core  

Hippo signalling as a nexus in host-virus interactions. [PDF]

PLoS Pathog
Bahrami A, Walter C, Ardestani A.
europepmc   +1 more source

Cut the YAP

JACC: Basic to Translational Science, 2020
Eric M. Small, Alan C. Brooks
openaire   +1 more source

IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis

Arthritis &Rheumatology, Accepted Article.
Background Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. Immunoglobulin G (IgG) from LN patients displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay, Alexia Orellana, George C. Tsokos, Rhea Bhargava   +3 more
wiley   +1 more source

Hippo-YAP Signaling Drives Epigenetic Vulnerability in the Diabetic Heart via the miR-22-3p-SIRT1 Axis: Linking Metabolic Stress to Chromatin Control. [PDF]

Diabetes
Jankauskas SS, Varzideh F, Santulli G.
europepmc   +1 more source

All‐Inside, All‐Soft‐Tissue, Anchor‐Free Meniscal Allograft Transplantation

Arthroscopy Techniques, EarlyView.
Abstract Meniscal allograft transplantation is an effective surgical option for patients with irreparable meniscal pathology, including chronic root tears, complex or radial tears, and prior meniscectomy. This Technical Note describes an all‐inside, all‐soft‐tissue, anchor‐free arthroscopic technique for meniscal allograft transplantation designed to ...
Seksan Kukreja, Kongphop Ratanachai, Wachirawit Penrat, Emmanuelle E. Yap, Bancha Chernchujit   +4 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Quercetin Inhibits Orthodontic Tooth Movement-Associated Periodontitis by Regulating Macrophage Aerobic Glycolysis Through the IL-17/Hippo/YAP Axis. [PDF]

Clin Exp Dent Res
Yao F, Song Z, Wu W, Liu B, Xia R, Zhou Y, Wang W, Chen Y, Liao Z.   +8 more
europepmc   +1 more source

Understanding the paradox of primary teacher shortage in low‐income countries: Insights from Malawi

British Educational Research Journal, EarlyView.
Abstract Malawi faces a persistent and chronic teacher shortage, particularly at the primary school level, with much of the challenge attributed to teacher supply constraints. While the causes of teacher shortages are known to be complex and context‐dependent, there remains a lack of in‐depth, country‐specific research to guide effective policies ...
Peter Mtika, Edward M. Sosu
wiley   +1 more source