Results 121 to 130 of about 78,875 (281)

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Patient-centred estimation of multimorbidity in chronic disease populations: a novel approach integrating global burden of disease metrics and healthcare administrative data

Population Health Metrics
Background Although chronic diseases represent a growing global health priority, significant gaps remain in understanding the burden of multimorbidity. This study developed an original methodology to estimate the burden of thirty major chronic diseases ...
Daniela Fortuna, Luana Caselli, Michele Romoli, Luca Vignatelli, Anna Elisabetta Vaudano, Jessica Mandrioli, Susanna Malagù, Massimo Costantini, Giuseppe Tibaldi, Gabriela Gildoni, Maria Guarino, Giuseppe Di Pasquale, Luca Iaboli, Lucia Alberghini, Marco Fusconi, Angela Maria Grazia Pacilli, Stefano Nava, Silvia Mancinelli, Maurizia Rolli   +18 more
doaj   +1 more source

BeBOD estimates of incidence, prevalence, and years lived with disability for 57 cancer types, 2004-2021

, 2023
Vanessa Gorasso, Robby De Pauw, Leonor Guariguata, Geert Silversmit, Brecht Devleesschauwer   +4 more
openalex   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

The prevalence and years lived with disability of asthma in children under 5 years old in Sichuan Southwest China, 1990-2019: A cross-sectional study. [PDF]

Front Pediatr, 2022
Luo Y, Bao L, Wang M, Guo H.
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Burden and causes of anemia in Vietnam: insights from the global burden of disease data

BMC Public Health
Background Anemia is a significant global health issue, impacting 1.92 billion people and ranking as a leading cause of disability. It is marked by low hemoglobin levels, which hinder oxygen delivery to vital organs and result from causes such as ...
Deepak Kumar Behera, Dil B. Rahut, Snehasish Tripathy, Sapna Negi   +3 more
doaj   +1 more source

Global, regional, and national burden of mental disorders and substance use disorders in older adults from 1990 to 2021: a systematic analysis and future trend prediction study

Frontiers in Psychiatry
IntroductionAs the global population ages, mental health has become a major public health issue affecting healthy aging. To estimate the burden, trends, and inequalities of mental disorders and substance use disorders (SUDs) among older adults aged ≥60 ...
Yitian Gao, Yitian Gao, Wanqiong Zhou, Qiuyi Wang, Qianyi Zhai, Lanshu Zhou, Lanshu Zhou   +6 more
doaj   +1 more source

Global, regional, and national years lived with disability due to blindness and vision loss from 1990 to 2019: Findings from the Global Burden of Disease Study 2019. [PDF]

Front Public Health, 2022
Li S, Ye E, Huang J, Wang J, Zhao Y, Niu D, Yue S, Huang X, Liu J, Hou X, Wu J.   +10 more
europepmc   +1 more source

Sensory Nerve‐Derived CGRP Controls Osteoclastogenesis by Limiting Macrophage Bioenergetics in Bone Repair

Advanced Science, EarlyView.
Sensory nerves help bones heal. This study shows that the neuropeptide CGRP, released from sensory nerves, slows down macrophage energy production, preventing excessive bone breakdown. By revealing this nerve–immune–metabolism connection, the work provides new insight into how the body balances bone repair and opens doors to targeted treatments ...
Jiaying Liu, Ting Zhang, Yuqing Mu, Lili Li, Ju Jin, Kevin J Dudley, Wendong Gao, Donglin Cai, Fuhua Yan, Lan Xiao, Yin Xiao   +10 more
wiley   +1 more source