Results 31 to 40 of about 538,506 (266)

Development of a Web-based calculator to estimate DALY and Productivity Losses due to COVID-19

Clinical Epidemiology and Global Health
Objectives: Ever since the emergence of COVID-19, health and the economy worldwide have witnessed a severe disruption, with infection spreading rapidly, covering 231 countries as of May 07, 2023.
Denny John, M.S. Narassima, Paramita Bhattacharya, Nirmalya Mukherjee, Jaideep Menon, Amitava Banerjee   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Life years lost due to cardiovascular diseases

Kardiologia Polska, 2013
When evaluating the health status of a population, an increasingly important role is played by measures aiming to access premature mortality in lost lifetime units. There is a considerable number of life years 'to be recovered' provided cardiovascular disease (CVD) mortality is reduced, as CVD cause the highest absolute number of years lost.To access ...
Irena, Maniecka-Bryła, Małgorzata, Pikala, Marek, Bryła   +2 more
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Establishing and mapping heat-sensitive disease spectrum in eastern China: A comprehensive analysis of 1.4 million deaths involving 14 major disease categories

Environment International
Background: Although high temperatures can affect multiple systems and organs, the comprehensive assessment of heat-sensitive diseases remains unclear. We aimed to establish the heat-related sensitive disease spectrum and assess the relative importance ...
Yiming Gai, Hong Su, Yinguang Fan, Wenjun Cheng, Xiaojie Zou, Yarui Fan, Yuefang Li, Zhen Ding, Jintao Liu, Yongmei Su, Zien Jin, Liwei Zhang, Yanan Ouyang, Yujia Zhai, Yiyun Ding, Chun Zhao, Jian Cheng, Hao Zheng   +17 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Beyond death counts: how COVID-19 affected excess mortality and productive life-years lost across 28 European states, 2020–2023

Frontiers in Public Health
IntroductionExcess mortality attributable to COVID-19 has been extensively investigated in the public health literature. This study extends the scope of previous findings by estimating three interrelated measures, excess deaths, excess Years of Life Lost,
Paweł Niewiadomski, Jakub Wojtasik, Błażej Łyszczarz   +2 more
doaj   +1 more source

The global burden of neglected zoonotic diseases: Current state of evidence

One Health, 2023
The majority of emerging infectious diseases are zoonoses, most of which are classified as “neglected”. By affecting both humans and animals, zoonoses pose a dual burden.
Carlotta Di Bari, Narmada Venkateswaran, Christina Fastl, Sarah Gabriël, Delia Grace, Arie H. Havelaar, Ben Huntington, Grace T. Patterson, Jonathan Rushton, Niko Speybroeck, Paul Torgerson, David M. Pigott, Brecht Devleesschauwer   +12 more
doaj   +1 more source