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Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Global Nitrogen Deposition Promotes Carbon Sink Formation in Terrestrial Ecosystems

Advanced Science, EarlyView.
Nitrogen deposition alleviates ecosystem N limitation and enhances carbon sinks. Using 829 observations, we show 36% of deposited N is retained globally (39.15 Tg N yr−1), with distinct NHx and NOy contributions. This retention drives a terrestrial C sink of 0.88 Pg C yr−1 (25.48%), highlighting the importance of pool‐specific C:N stoichiometry ...
Lei Li, Mingyu Xie, Nan Jia, Li‐Dong Mo, Qiang Yu, Fanjiang Zeng, Xiangyi Li   +6 more
wiley   +1 more source

Valuing risks to life and health: towards consistent transfer estimates in the European Union and accession states [PDF]

, 2000
Pearce, D.W.
core  

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Life expectancy and potential years of life lost for schizophrenia in western China

Psychiatry Research, 2022
Excess mortality in people with schizophrenia has been extensively reported. However, little is known about the life expectancy and potential years of life lost (PYLL) in western China. This study aimed to estimated life expectancy and PYLL for people with schizophrenia in western China.
Xiang, Liu, Dan, Wang, Ruoxin, Fan, Rongke, Wang, Hu, Xiang, Xianmei, Yang, Yuanyuan, Liu   +6 more
openaire   +4 more sources

Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis

The Lancet Psychiatry, 2017
Several studies and meta-analyses have shown that mortality in people with schizophrenia is higher than that in the general population but have used relative measures, such as standardised mortality ratios. We did a systematic review and meta-analysis to estimate years of potential life lost and life expectancy in schizophrenia, which are more direct ...
Hjorthoj, Carsten, Sturup, Anne Emilie, McGrath, John J., Nordentoft, Merete   +3 more
openaire   +6 more sources

Years of Potential Life Lost (YPLL)—What Does it Measure?

Epidemiology, 1990
The concept of years of potential life lost (YPLL) involves estimating the average time a person would have lived had he or she not died prematurely. This measure is used to help quantify social and economic loss owing to premature death, and it has been promoted to emphasize specific causes of death affecting younger age groups.
J W, Gardner, J S, Sanborn
openaire   +2 more sources