Results 81 to 90 of about 2,210,830 (297)

Burden of smoking in Lithuania: attributable mortality and years of potential life lost [PDF]

European Journal of Public Health, 2017
High mortality rates from smoking related diseases are a significant public health issue in Lithuania. Study aims to estimate the number of smoking attributable deaths (SADs) and years of potential life lost in Lithuania in 2013.Gender, age and disease specific mortality was calculated by applying the smoking attributable fractions (SAFs) to prevalence
Vaida, Liutkute, Aurelijus, Veryga, Mindaugas, Štelemekas, Nijole, Goštautaite Midttun   +3 more
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Analysis of diabetes mortality characteristics and potential years of life lost among residents of Huangpu District， Shanghai， 1993‒2021

Shanghai yufang yixue
ObjectiveTo investigate the trends in diabetes mortality and potential years of life lost (PYLL) among residents of Huangpu District, Shanghai from 1993 to 2021, to analyze the long-term trends of diabetic patients with different characteristics and to ...
LI Weiyi, ZHAO Junfeng, MAO Yuming, WANG Yi, ZUO Zhenzi, GAO Qiang, SHI Junling   +6 more
doaj   +1 more source

What is a premature death? [PDF]

, 2007
The one who dies is deprived of goods that this person would have enjoyed if he or she had continued living, according to the popular “deprivation account of harm.” The person who dies “prematurely” is generally thought to suffer the most harm from death.
Trisel, Brooke Alan
core  

The regulatory cliff edge between contraception and abortion: the legal and moral significance of implantation [PDF]

, 2015
In regulating the voluntary interruption of pregnancy, English law has accorded particular significance to two biological events. First, ‘viability’, the moment when a fetus is said to acquire the capacity for independent life, plays an important role in
Campbell, Dickens, Goldthorp, Hursthouse, Husak, Keown, Lie, Noe, Packer, Potts, Prescription Only Medicines (Human Use) Order, Raymond, Sally Sheldon, Steinbock, Swahn, Taylor, Tunkel, Tunkel, Wilcox, Wilcox, Williams   +20 more
core   +3 more sources

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Effects of growth rate, size, and light availability on tree survival across life stages: a demographic analysis accounting for missing values and small sample sizes. [PDF]

, 2015
The data set supporting the results of this article is available in the Dryad repository, http://dx.doi.org/10.5061/dryad.6f4qs. Moustakas, A. and Evans, M. R.
A Matossian, A Moustakas, A Moustakas, A Moustakas, A Moustakas, A Moustakas, Aristides Moustakas, C Bigler, C Bigler, C Lusk, CE Frangakis, D Gravel, DA Coomes, DS Falster, E Jones, E Jones, EV Groeneveld, F Abadi, F Colchero, F Serinaldi, FJ Sterck, G Chen, G Kunstler, G Lahoreau, GC Jacoby, GC White, GC White, H Flores-Moreno, H Pretzsch, HA Meyer, HM Alexander, I Szabo, J Peñuelas, J Piffady, JF Franklin, JH Brown, JP Caspersen, JR Packham, K Hemming, KP Burnham, L Nieto-Barajas, M Atkinson, M Beaudet, M Kery, M Kéry, M Ugarte, M Westoby, M Žukovič, Matthew R Evans, MR Evans, MR Evans, MR Evans, MS Zens, P García-Soidán, P Harcombe, P Rock, P Wardle, PH Wyckoff, R Harmer, R Pradel, R Tsujino, RK Kobe, RK Kobe, RM Dorazio, RP Shefferson, S Fraver, S Pledger, S Schwinning, SW Pacala, TJ Givnish, X Song, X Wang, Y Onoda   +72 more
core   +4 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Global burden of injuries attributable to alcohol consumption in 2004: a novel way of calculating the burden of injuries attributable to alcohol consumption

Population Health Metrics, 2012
Background Alcohol consumption is a major risk factor for injuries; however, international data on this burden are limited. This article presents new methods to quantify the burden of injuries attributable to alcohol consumption and quantifies the number
Shield Kevin D, Gmel Gerrit, Patra Jayadeep, Rehm Jürgen   +3 more
doaj   +1 more source

Years of life potentially lost in traffic accident victims

, 2022
Objetivo: Avaliar a tendência e os anos de vida potencialmente perdidos em mortes por acidentes de trânsito no departamento de Tacna. Material e métodos: Estudo observacional baseado em dados secundários do Sistema Nacional de Óbitos do Ministério dá Saúde.
Román-Lazarte, Víctor, Román, Luz A., Sanga, Hoxanna, Tarqui, Lissell   +3 more
openaire   +1 more source