Results 61 to 70 of about 89,535 (262)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Hubble Space Telescope Observations of 3200 Phaethon At Closest Approach
, 2018 We present Hubble Space Telescope observations of the active asteroid (and Geminid stream parent) 3200 Phaethon when at its closest approach to Earth (separation 0.07 AU) in 2017 December.
Agarwal, Jessica +3 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Robust Geometry Estimation using the Generalized Voronoi Covariance Measure [PDF]
, 2015 The Voronoi Covariance Measure of a compact set K of R^d is a tensor-valued measure that encodes geometric information on K and which is known to be resilient to Hausdorff noise but sensitive to outliers. In this article, we generalize this notion to any
Cuel, Louis +3 more
core +4 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Overview of Seafood Research at Ashtown Food Research Centre (1990 - 2007) [PDF]
, 2008 End of project reportIn recent years, the Irish seafood industry has faced stringent quotas and dwindling fish stocks. The introduction of fish farming added a new dimension but falling prices also created difficulties for this sector.
Gormley, Ronan T.
core
Optimal B-spline bases for the numerical solution of fractional differential problems [PDF]
, 2018 Efficient numerical methods to solve fractional differential problems are particularly required in order to approximate accurately the nonlocal behavior of the fractional derivative.
Pitolli, Francesca
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Turkish Journal of Agriculture: Food Science and TechnologyThe aesthetic and functional quality of urban landscapes is strongly influenced by the seasonal color dynamics of vegetation. This research was conducted between September 2013 and December 2014 to investigate the autumn color changes of three tree ...
Elif Bozdoğan Sert +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source