Results 161 to 170 of about 2,175,763 (309)

Machine learning-assisted design of Ti–V–Nb–Mo refractory high-entropy alloys with higher ductility and specific yield strength

Yan Li, Junjie Gong, Shilong Liang, Wu Wei, Yongxin Wang, Zheng Chen   +5 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Multi-Decadal Analysis on the Impact of Climate Change, Genetic Gain, Cultivar Type, and Harvest Timing on Main and Ratoon Rice Yield and Quality. [PDF]

Glob Chang Biol
Wilson LT, Samonte SOPB, Yang Y.
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Variations in Nodule Microbial Communities and Their Association with Root-Colonizing Arbuscular Mycorrhizal Fungi in Medicago Sativa. [PDF]

Microb Ecol
Zhang Y, Zheng C, Wang S, Zhu F.
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Breeding climate-resilient wheat for Nepalese agricultural system under diverse abiotic stresses using an integrated AMMI, GGE and stress tolerance indices. [PDF]

Sci Rep
Bhandari R, Poudel MR, Paudel H, Neupane MP, Solanki P, Kushwaha UKS.   +5 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Accelerating High-Entropy Alloy Design via Machine Learning: Predicting Yield Strength from Composition. [PDF]

Materials (Basel)
Lee S, Sohn SS, Lee HS, Kim D, Kang Y.
europepmc   +1 more source

Diagnostic Yield of Incremental Biopsy Cores and Second Lesion Sampling for In-Gantry MRI-Guided Prostate Biopsy

, 2020
Nicole Seyfried, Amr Mahran, Ananya Panda, Verena Carola Obmann, Christina Buzzy, Yun Jiang, Katherine Landau Wright, Dean Nakamoto, Indravadan Patel, Britt Conroy, Lee Ponsky, Vikas Gulani   +11 more
openalex   +2 more sources