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Agriculture and climate change are internally correlated with each other in various aspects, as climate change is the main cause of biotic and abiotic stresses, which have adverse effects on the agriculture of a region. The land and its agriculture are being affected by climate changes in different ways, e.g., variations in annual rainfall, average ...openaire +1 more sourceGenetic studies of body mass index yield new insights for obesity biology
Nature, 2015 A. Locke, Bratati Kahali, S. Berndt, A. Justice, T. Pers, F. Day, Corey Powell, S. Vedantam, Martin L. Buchkovich, Jian Yang, Damien C. Croteau-Chonka, T. Esko, T. Fall, T. Ferreira, S. Gustafsson, Z. Kutalik, J. Luan, R. Mägi, J. Randall, T. Winkler, A. Wood, T. Workalemahu, J. Faul, Jennifer A. Smith, J. Zhao, Wei Zhao, Jin Chen, R. Fehrmann, Å. Hedman, J. Karjalainen, Ellen M. Schmidt, D. Absher, N. Amin, Denise Anderson, M. Beekman, J. Bolton, J. Bragg-Gresham, S. Buyske, A. Demirkan, Guohong Deng, G. Ehret, B. Feenstra, M. Feitosa, K. Fischer, A. Goel, Jian Gong, A. Jackson, S. Kanoni, M. Kleber, K. Kristiansson, U. Lim, Vaneet Lotay, M. Mangino, I. M. Leach, C. Medina-Gomez, S. Medland, M. Nalls, Cameron D. Palmer, D. Pasko, S. Pechlivanis, M. Peters, I. Prokopenko, D. Shungin, A. Stančáková, R. Strawbridge, Y. Sung, Toshiko Tanaka, A. Teumer, S. Trompet, S. W. Laan, J. V. Setten, J. V. Vliet-Ostaptchouk, Zhaoming Wang, L. Yengo, Weihua Zhang, A. Isaacs, E. Albrecht, J. Ärnlöv, Gillian M. Arscott, A. Attwood, S. Bandinelli, Amy Barrett, Isabelita N. Bas, C. Bellis, A. Bennett, C. Berne, R. Blagieva, M. Blüher, S. Böhringer, L. Bonnycastle, Y. Böttcher, H. Boyd, M. Bruinenberg, I. H. Caspersen, Y. I. Chen, R. Clarke, E. W. Daw, A. Craen, G. Delgado, M. Dimitriou, A. Doney, N. Eklund, K. Estrada, Elodie Eury, L. Folkersen, Ross M. Fraser, M. Garcia, F. Geller, V. Giedraitis, B. Gigante, A. Go, A. Golay, A. Goodall, S. Gordon, Mathias Gorski, H. Grabe, H. Grallert, T. Grammer, J. Grässler, H. Grönberg, C. Groves, G. Gusto, J. Haessler, P. Hall, T. Haller, G. Hallmans, C. Hartman, M. Hassinen, C. Hayward, N. Heard-Costa, Q. Helmer, C. Hengstenberg, O. Holmen, J. Hottenga, A. James, Janina M. Jeff, Å. Johansson, J. Jolley, Thorhildur Juliusdottir, L. Kinnunen, W. Koenig, M. Koskenvuo, W. Kratzer, J. Laitinen, C. Lamina, K. Leander, N. Lee, P. Lichtner, L. Lind, J. Lindström, K. S. Lo, S. Lobbens, R. Lorbeer, Yingchang Lu, F. Mach, P. Magnusson, A. Mahajan, W. McArdle, S. McLachlan, C. Menni, S. Merger, E. Mihailov, L. Milani, A. Moayyeri, K. Monda, M. Morken, A. Mulas, G. Müller, M. Müller-Nurasyid, A. Musk, R. Nagaraja, M. Nöthen, I. Nolte, S. Pilz, N. W. Rayner, Frida Renstrom, R. Rettig, J. Ried, S. Ripke, N. Robertson, L. Rose, S. Sanna, H. Scharnagl, S. Scholtens, F. Schumacher, W. Scott, T. Seufferlein, Jianxin Shi, A. Smith, Joanna Smolonska, A. Stanton, V. Steinthorsdottir, K. Stirrups, H. Stringham, J. Sundström, M. Swertz, A. Swift, A. Syvänen, S. Tan, B. Tayo, B. Thorand, G. Thorleifsson, J. Tyrer, H. Uh, L. Vandenput, F. Verhulst, S. Vermeulen, N. Verweij, J. Vonk, L. Waite, H. Warren, D. Waterworth, M. Weedon, L. Wilkens, C. Willenborg, T. Wilsgaard, M. Wojczynski, A. Wong, A. Wright, Qunyuan Zhang, E. Brennan, Murim Choi, Z. Dastani, A. Drong, P. Eriksson, A. Franco-Cereceda, J. Gådin, A. Gharavi, M. Goddard, R. Handsaker, Jinyan Huang, F. Karpe, S. Kathiresan, S. Keildson, K. Kiryluk, M. Kubo, Jong-Young Lee, L. Liang, R. Lifton, Baoshan Ma, S. Mccarroll, A. McKnight, J. Min, M. Moffatt, G. Montgomery, J. Murabito, G. Nicholson, D. Nyholt, Y. Okada, J. Perry, R. Dorajoo, E. Reinmaa, R. Salem, N. Sandholm, R. Scott, L. Stolk, A. Takahashi, Toshihiro Tanaka, F. V. Hooft, Anna A. E. Vinkhuyzen, H. Westra, W. Zheng, K. Zondervan, A. Heath, D. Arveiler, S. Bakker, J. Beilby, R. Bergman, J. Blangero, P. Bovet, H. Campbell, M. Caulfield, G. Cesana, A. Chakravarti, D. Chasman, P. Chines, F. Collins, D. Crawford, L. Cupples, D. Cusi, J. Danesh, U. Faire, H. M. Ruijter, A. Dominiczak, R. Erbel, J. Erdmann, J. Eriksson, M. Farrall, S. Felix, E. Ferrannini, J. Ferrières, I. Ford, N. Forouhi, T. Forrester, O. Franco, R. Gansevoort, P. Gejman, C. Gieger, O. Gottesman, V. Gudnason, U. Gyllensten, A. Hall, T. Harris, A. Hattersley, A. Hicks, L. Hindorff, A. Hingorani, A. Hofman, G. Homuth, G. K. Hovingh, S. Humphries, S. Hunt, E. Hyppönen, T. Illig, K. Jacobs, M. Jarvelin, K. Jöckel, B. Johansen, P. Jousilahti, J. Jukema, A. Jula, J. Kaprio, J. Kastelein, S. Keinanen-Kiukaanniemi, L. Kiemeney, P. Knekt, J. Kooner, C. Kooperberg, P. Kovacs, A. Kraja, M. Kumari, J. Kuusisto, T. Lakka, C. Langenberg, L. Marchand, T. Lehtimäki, V. Lyssenko, S. Männistö, A. Marette, T. Matise, C. McKenzie, B. McKnight, F. Moll, A. Morris, A. Morris, J. Murray, M. Nelis, C. Ohlsson, A. Oldehinkel, K. Ong, P. Madden, G. Pasterkamp, J. Peden, A. Peters, D. Postma, P. Pramstaller, J. Price, L. Qi, O. Raitakari, T. Rankinen, D. Rao, T. Rice, P. Ridker, J. Rioux, M. Ritchie, I. Rudan, V. Salomaa, N. Samani, J. Saramies, M. Sarzynski, H. Schunkert, P. Schwarz, P. Sever, A. Shuldiner, J. Sinisalo, R. Stolk, K. Strauch, A. Tönjes, D. Trégouët, A. Tremblay, E. Tremoli, J. Virtamo, M. Vohl, U. Völker, G. Waeber, G. Willemsen, J. Witteman, M. Zillikens, L. Adair, P. Amouyel, F. Asselbergs, T. Assimes, M. Bochud, B. Boehm, E. Boerwinkle, S. Bornstein, E. Bottinger, C. Bouchard, S. Cauchi, J. Chambers, S. Chanock, R. Cooper, P. D. Bakker, G. Dedoussis, L. Ferrucci, P. Franks, P. Froguel, L. Groop, C. Haiman, A. Hamsten, J. Hui, D. Hunter, K. Hveem, R. Kaplan, M. Kivimaki, D. Kuh, M. Laakso, Yongmei Liu, N. Martin, W. März, M. Melbye, A. Metspalu, S. Moebus, P. Munroe, I. Njølstad, B. Oostra, C. Palmer, N. Pedersen, M. Perola, L. Pérusse, U. Peters, C. Power, T. Quertermous, R. Rauramaa, F. Rivadeneira, T. Saaristo, D. Saleheen, N. Sattar, E. Schadt, D. Schlessinger, P. Slagboom, H. Snieder, T. Spector, U. Thorsteinsdóttir, M. Stumvoll, J. Tuomilehto, A. Uitterlinden, M. Uusitupa, P. Harst, M. Walker, H. Wallaschofski, N. Wareham, H. Watkins, D. Weir, H. Wichmann, James F. Wilson, P. Zanen, I. Borecki, P. Deloukas, C. Fox, I. Heid, J. O’Connell, D. Strachan, K. Stefánsson, C. Duijn, G. Abecasis, L. Franke, T. Frayling, M. McCarthy, P. Visscher, A. Scherag, C. Willer, M. Boehnke, K. Mohlke, C. Lindgren, J. Beckmann, I. Barroso, K. North, E. Ingelsson, J. Hirschhorn, R. Loos, Elizabeth K. Speliotes +481 moresemanticscholar +1 more sourceFrom omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.Siobhán O'Sullivan, Lu Qi, Pierre Zalloua +2 morewiley +1 more sourceMycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo +10 morewiley +1 more sourceMaximizing yield
Poultry Science, 1997 Genetic selection for edible meat yield will intensify as a result of market demands. Phenotypic selection in larger populations using nondestructive lean tissue estimation, more progeny and sibling carcass measurement, inclusion of female lines, and marker assisted selection will provide the means.openaire +2 more sourcesERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen +3 morewiley +1 more sourceCell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens +17 morewiley +1 more source
