Results 161 to 170 of about 1,866,769 (265)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Restoring soil functionality and improving wheat yield through integrated farmyard manure, compost, crop residues and decomposition enhancers. [PDF]

BMC Plant Biol
Kalim M, Khan M, Ahmad H, Ali M, Aslam S, Altaf MT, Jan MF, Liaqat W.   +7 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

DEĞİŞİK YAŞLI GÖKNAR MEŞCERELERİNDE BONİTET VE YETİŞME ORTAMI ÖZELLİKLERİ ARASINDAKİ İKİLİ İLİŞKİLER (TWO-VARRIABLE RELATION BETWEEN SITE INDEX AND SITE CHARACTERISTICS IN THE UNEVENAGED FIR STANDS OF BLACKSEA REGION)

Forestist, 1989
Ömer Saraçoğlu
doaj   +2 more sources

Application of NGS Technology, Association Mapping, and Physical Mapping Technologies to Identify Candidate Genes Associated with Maize (<i>Zea mays</i> L.) Hybrid Yield. [PDF]

Int J Mol Sci
Bocianowski J, Tomkowiak A, Wagner E, Lipiński D.   +3 more
europepmc   +1 more source