Results 241 to 250 of about 2,175,763 (309)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Improving oat yield and lodging resistance through nitrogen fertilization in the Alpine Qinghai-Tibet Plateau. [PDF]

Front Plant Sci
Zhang R, Wu R, Liu W, Liang G, Ju Z.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Advances in high-throughput mutation breeding systems integrating atmospheric and room-temperature plasma (ARTP) with droplet-based microfluidics. [PDF]

Microb Cell Fact
Xu L, Guo M, Jiang D, Jiang J, Lu L.
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Cross-Electrophile Coupling of <i>N</i>-Hydroxyphthalimide Esters with Aryl Bromides Using an Inner-Sphere Homogeneous Reductant. [PDF]

J Am Chem Soc
Ganguli K, Cruz AR, Diccianni JB, García-Reynaga P, Weix DJ.   +4 more
europepmc   +1 more source

Efficient one-pot quinoline derivative synthesis from acetophenone and allyl alcohols. [PDF]

RSC Adv
Zeng F, Xu Y, Fang J, Xu H, Cai Y, Hong Y, Gao J, Zeng Q, Su X.   +8 more
europepmc   +1 more source

Genotype × environment interactions and genetic variation reveal stable, high-yielding, and organosulfur-rich garlic cultivars adapted to tropical conditions. [PDF]

Sci Rep
Baswarsiati B, Harsonowati W, Pramanik D, Arifin Z, Tafakresnanto C, Krismawati A, Latifah E, Handayati W, Yulianti F, Khamidah A, Al Farraj DA, Iqbal R, Malaga-Tobola U, Gancarz M.   +13 more
europepmc   +1 more source

Enhancing the yield of bucket brigade quantum random access memory using redundancy repair. [PDF]

Sci Rep
Kim D, Heng S, Lee S, Han Y.
europepmc   +1 more source

Regulatory role of rhizosphere microbial structure and function in yield formation of ratooning season rice. [PDF]

BMC Plant Biol
Wang Z, Bai L, Dong S, Yang D, Tong Z, Zhong F, Zi H, Zeng Y, Chen M, Xu H, Zhang B, Lin W, Zhang Z.   +12 more
europepmc   +1 more source