Results 101 to 110 of about 1,990,499 (312)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

POLICY IMPLICATIONS ON THE REDUCTION OF NITROGEN FERTILIZER USE ON NON-IRRIGATED CORN-WINTER WHEAT PRODUCTION IN NORTH ALABAMA [PDF]

Environmental and economic effects of nitrogen fertilizer reduction on North Alabama small farms are evaluated using GPFARM. GPFARM incorporates climate, soil data and management practices to simulate science and economic analysis for a farm/ranch ...
Befecadu, Joseph, Jones, Hezekiah, Joseph, Barbara A.   +2 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Optimizing Maize Agronomic Performance Through Adaptive Management Systems in the Mid-Atlantic United States

Agronomy
Maize (corn) (Zea mays L.) yield is influenced by complex factors, including abiotic and biotic stress and inconsistent nutrient use efficiency, which challenge optimal yield.
Unius Arinaitwe, Wade Thomason, William Hunter Frame, Mark S. Reiter, David Langston   +4 more
doaj   +1 more source

SOIL FERTILITY MANAGEMENT AND AGRICULTURAL PRODUCTIVITY IN MALAWI [PDF]

In this paper we analyze the factors that influence the productivity of maize among smallholder farmers. We use farm-household survey data in order to compare the productivity of smallholder maize production under integrated (ISFM) and chemical-based ...
Sauer, Johannes, Tchale, Hardwick
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Assessment of performance and impact of irrigation and water resources systems in Taiwan and Sri Lanka [PDF]

Irrigation systems / Water scarcity / Water allocation / Water supply / Water quality / Water distribution / Decision making / Water management / Regression analysis / Performance evaluation / Sustainability / Irrigated farming / Agricultural development
Aloysius, N., Matsuno,Y., Sakthivadivel,R.   +2 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Role of Nitrogen Fertilization and Sowing Date in Productivity and Climate Change Adaptation Forecast in Rice–Wheat Cropping System

Nitrogen
Global food security is at risk due to climate change. Soil fertility loss is among the impacts of climate change which reduces the productivity of rice–wheat cropping systems.
Khalid Hussain, Erdoğan Eşref Hakki, Ayesha Ilyas, Sait Gezgin, Muhammad Asif Kamran   +4 more
doaj   +1 more source

Intergenerational Equity and the Forest Management Problem [PDF]

The paper re-examines the foundations of representation of intertemporal preferences that satisfy intergenerational equity, and provides an axiomatic characterization of those social welfare relations, which are representable by the utilitarian ordering,
Mitra, Tapan
core