Results 101 to 110 of about 1,980,669 (311)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Optimizing Maize Agronomic Performance Through Adaptive Management Systems in the Mid-Atlantic United States

Agronomy
Maize (corn) (Zea mays L.) yield is influenced by complex factors, including abiotic and biotic stress and inconsistent nutrient use efficiency, which challenge optimal yield.
Unius Arinaitwe, Wade Thomason, William Hunter Frame, Mark S. Reiter, David Langston   +4 more
doaj   +1 more source

Genetic potential for grain yield in spring barley varieties and variety mixtures in variable organic environments [PDF]

, 2006
For organic crop production, well-characterised varieties increase the possibilities for controlling diseases and weeds and compensating for deficits in nutrients.
Hovmøller, Mogens, Kristensen, Kristian, Willas, Jakob, Østergård, Hanne   +3 more
core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Sunflower Planting Date x Variety Trial [PDF]

, 2016
Sunflowers are being grown in the Northeast for their potential to add value to a diversified operation as fuel, feed, fertilizer, and an important rotational crop.
Brigham, Nate, Cubins, Julija, Darby, Heather, Gupta, Abha, Ziegler, Sara   +4 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Role of Nitrogen Fertilization and Sowing Date in Productivity and Climate Change Adaptation Forecast in Rice–Wheat Cropping System

Nitrogen
Global food security is at risk due to climate change. Soil fertility loss is among the impacts of climate change which reduces the productivity of rice–wheat cropping systems.
Khalid Hussain, Erdoğan Eşref Hakki, Ayesha Ilyas, Sait Gezgin, Muhammad Asif Kamran   +4 more
doaj   +1 more source

Management affects nitrate leaching from organic farms [PDF]

, 2013
Management decisions significantly affect nitrate-N leaching (N-leaching) from comparable organic fields. The main concern is field management during autumn and themanagement of grass leys.
Askegaard, Margrethe, Eriksen, J.
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source