Results 91 to 100 of about 3,154,862 (212)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Yield Curve Dynamics: Regional Common Factor Model [PDF]
In this paper, we focus on thorough yield curve modelling. We build on extended classical Nelson-Siegel model, which we further develop to accommodate unobserved regional common factors.
Boril Šopov, Jakub Seidler
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Enhancing AquaCrop model precision for accurate simulation of sweet potato and taro landraces
Frontiers in Sustainable Food SystemsNeglected and underutilised crop species (NUS) such as orange-fleshed sweet potato (OFSP) and taro are nutrient-dense, climate-resilient crops with high potential to diversify food systems.
Thando Lwandile Mthembu +6 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Comparative Evaluation of Some Crop Yield Prediction Models using Tropical Cowpea Yield-Weather Data
, 2009 A computer program was adopted from the work of Hill et al. (1982) to calibrate and test three of the existing yield prediction models using tropical cowpea yieldÐweather data. The models tested were Hanks Model (first and second versions). Stewart Model
DA Okunade +3 more
core +1 more source
Prediction of Rice Yield via Stacked LSTM
, 2020 In order to guarantee the rice yield more effectively, the prediction of rice yield should be taken into account. Because the rice yield every year can be seen as a sequence of time series, many methods applied in prediction of time series can be ...
Muyan Liu, Qiufeng Wu, Xiangyan Meng
core +1 more source
Prediction of Synthesis Yield of Polymethoxy Dibutyl Ether Under Small Sample Conditions
MoleculesIn chemical reaction processes, yield prediction frequently faces challenges, such as multi-variable coupling, significant nonlinearity, and the limited accuracy of traditional mechanistic models.
Xue Wang +4 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source