Results 91 to 100 of about 290,141 (263)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Simulation of strawberry yield using dry matter distribution based on the potential growth of the sink–source organs

Frontiers in Plant Science
Strawberry, a vital crop in horticulture, faces challenges like pest infestations and climate variability that affect stable production. A crop model based on photosynthesis-derived dry matter (DM) production is an effective method to examine the ...
Tomomi Sugiyama, Yusuke Kakei, Yasunaga Iwasaki, Atsushi Oda, Masahide Isozaki   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Utilizing vegetation indices with optimal wavelengths to predict nitrogen uptake at the flowering stage and wheat yield

Plant Production Science
Techniques for determining the amount of nitrogen topdressing based on remote sensing during the flowering stage of wheat require highly accurate yield predictions. Optimal wavelength combinations for accurately predicting nitrogen uptake and wheat yield
Akina Mizumoto, Hiroko Sawada, Ryo Terasaki, Kou Nakazono, Hiroe Yoshida, Akihiro Ohsumi, Akira Fukushima   +6 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Sensor-Based Yield Prediction in Durum Wheat Under Semi-Arid Conditions Using Machine Learning Across Zadoks Growth Stages

Remote Sensing
Yield prediction in wheat cultivated under semi-arid climatic conditions is gaining increasing importance for sustainable production strategies and decision support systems.
Süreyya Betül Rufaioğlu, Ali Volkan Bilgili, Erdinç Savaşlı, İrfan Özberk, Salih Aydemir, Amjad Mohamed Ismael, Yunus Kaya, João P. Matos-Carvalho   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Enhancing AquaCrop model precision for accurate simulation of sweet potato and taro landraces

Frontiers in Sustainable Food Systems
Neglected and underutilised crop species (NUS) such as orange-fleshed sweet potato (OFSP) and taro are nutrient-dense, climate-resilient crops with high potential to diversify food systems.
Thando Lwandile Mthembu, Richard Kunz, Tafadzwanashe Mabhaudhi, Tafadzwanashe Mabhaudhi, Tafadzwanashe Mabhaudhi, Tafadzwanashe Mabhaudhi, Shaeden Gokool   +6 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Prediction of Synthesis Yield of Polymethoxy Dibutyl Ether Under Small Sample Conditions

Molecules
In chemical reaction processes, yield prediction frequently faces challenges, such as multi-variable coupling, significant nonlinearity, and the limited accuracy of traditional mechanistic models.
Xue Wang, Linyu Lu, Qiuxin Ma, Hongyan Shang, Lanyi Sun   +4 more
doaj   +1 more source