Results 101 to 110 of about 321,230 (311)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Yield-SAFE: A parameter-sparse, process-based dynamic model for predicting resource capture, growth, and production in agroforestry systems. [PDF]

, 2007
1. Silvoarable agroforestry (SAF) is the cultivation of trees and arable crops on the same parcel of land. SAF may contribute to modern diversified land use objectives in Europe, such as enhanced biodiversity and productivity, reduced leaching of ...
Dupraz, Christian, Keesman, K.J., Dupraz, C., Metselaar, K., Mayus, M.M., Keulen, H., van, Pilbeam, David, Keesman, Karel, Burgess, Paul, Palma, Joao, Werf, W., van der, Burgess, Paul J., Pilbeam, D., van Keulen, Herman, van der Werf, W., Graves, Anil, Palma, João H. N., Stappers, Roel, van Keulen, H., Incoll, L. D., Incoll, L.D., van der Werf, Wopke, Metselaar, Klaas, Mayus, Martina, Stappers, R.J.J., Palma, J.H.N., Burgess, P.J., Graves, A.R.   +27 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Integrating multi-modal remote sensing, deep learning, and attention mechanisms for yield prediction in plant breeding experiments

Frontiers in Plant Science
In both plant breeding and crop management, interpretability plays a crucial role in instilling trust in AI-driven approaches and enabling the provision of actionable insights.
Claudia Aviles Toledo, Melba M. Crawford, Melba M. Crawford, Mitchell R. Tuinstra   +3 more
doaj   +1 more source

Inverse meta-modelling to estimate soil available water capacity at high spatial resolution across a farm

, 2011
Geo-referenced information on crop production that is both spatially- and temporally-dense would be useful for management in precision agriculture (PA). Crop yield monitors provide spatially but not temporally dense information.
Whelan, B.M., Florin, M.J., McBratney, A.B., Minasny, B.   +3 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Application of Decision Tree (M5Tree) Algorithm for Multicrop Yield Prediction of the Semi-Arid Region of Maharashtra, India [PDF]

Journal of Soft Computing in Civil Engineering
India, with a population of 1.40 billion, is the most populous country in the world, necessitating increased food production. For making decisions about issues relating to food security, reliable crop yield estimation is essential.
Kalpesh Borse, Prasit Agnihotri
doaj   +1 more source

2018 Australian Cotton Conference [PDF]

, 2018
UAVs enable fast, high resolution image capture of cotton fields. These images are typically assessed manually to identify areas of stress or reduced productivity.
McCarthy, Alison, Foley, Joseph
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Predicting real growth using the yield curve [PDF]

A study using out-of-sample regressions to determine how well the 10-year, 3-month yield spread predicts future real GDP growth. The author finds that although the yield curve is a good predictor over the entire 30-year sample period, it has become much ...
Ann M. Dombrosky, Joseph G. Haubrich
core