Results 91 to 100 of about 292,995 (264)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Sensitive Multispectral Variable Screening Method and Yield Prediction Models for Sugarcane Based on Gray Relational Analysis and Correlation Analysis

Remote Sensing
Sugarcane yield prediction plays a pivotal role in enabling farmers to monitor crop development and optimize cultivation practices, guiding harvesting operations for sugar mills. In this study, we established three experimental fields, which were planted
Shimin Zhang, Huojuan Qin, Xiuhua Li, Muqing Zhang, Wei Yao, Xuegang Lyu, Hongtao Jiang   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Simulation of strawberry yield using dry matter distribution based on the potential growth of the sink–source organs

Frontiers in Plant Science
Strawberry, a vital crop in horticulture, faces challenges like pest infestations and climate variability that affect stable production. A crop model based on photosynthesis-derived dry matter (DM) production is an effective method to examine the ...
Tomomi Sugiyama, Yusuke Kakei, Yasunaga Iwasaki, Atsushi Oda, Masahide Isozaki   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Utilizing vegetation indices with optimal wavelengths to predict nitrogen uptake at the flowering stage and wheat yield

Plant Production Science
Techniques for determining the amount of nitrogen topdressing based on remote sensing during the flowering stage of wheat require highly accurate yield predictions. Optimal wavelength combinations for accurately predicting nitrogen uptake and wheat yield
Akina Mizumoto, Hiroko Sawada, Ryo Terasaki, Kou Nakazono, Hiroe Yoshida, Akihiro Ohsumi, Akira Fukushima   +6 more
doaj   +1 more source

Predicting cotton yields

California Agriculture, 1976
California Agriculture - All ...
openaire   +1 more source

On Convolutional Vision Transformers for Yield Prediction

CoRR
While a variety of methods offer good yield prediction on histogrammed remote sensing data, vision Transformers are only sparsely represented in the literature. The Convolution vision Transformer (CvT) is being tested to evaluate vision Transformers that are currently achieving state-of-the-art results in many other vision tasks.
Alvin Inderka, Florian Huber, Volker Steinhage   +2 more
openaire   +2 more sources