Results 211 to 220 of about 576,522 (312)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Ultraviolet-Follow Curing-Mediated Extrusion Stabilization for Low-Yield-Stress Silicone Rubbers: From Die Swell Suppression to Dimensional Accuracy Enhancement. [PDF]

Polymers (Basel)
Liu B, Ma B.
europepmc   +1 more source

Aspiration-assisted freeform bioprinting of prefabricated tissue spheroids in a yield-stress gel. [PDF]

Commun Phys, 2020
Ayan B, Celik N, Zhang Z, Zhou K, Kim MH, Banerjee D, Wu Y, Costanzo F, Ozbolat IT.   +8 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

From yield stress to elastic instabilities: Tuning the extensional behavior of elastoviscoplastic fluids. [PDF]

PNAS Nexus
Abdelgawad MS, Haward SJ, Shen AQ, Rosti ME.   +3 more
europepmc   +1 more source

Mastering Yield Stress Evolution and Formwork Friction for Smart Dynamic Casting. [PDF]

Materials (Basel), 2020
Szabo A, Reiter L, Lloret-Fritschi E, Gramazio F, Kohler M, Flatt RJ.   +5 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The grouting plugging mechanism of layered jointed rock mass considering the time-varying yield stress of grout. [PDF]

Sci Rep
Yalei Z, Kepeng H, Zongyong W, Shifei Y, Yunlin Y, Yong Y.   +5 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source