Results 271 to 280 of about 9,596,460 (344)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
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Current Opinion in Colloid & Interface Science, 2019
Abstract Recent years have seen a flurry of research on yield stress fluids, approached from different perspectives (physicochemical, rheological and fluid mechanical), considering different length scales and timescales, using a range of tools: experimental, computational and analytical.
I. Frigaard
openaire +2 more sources
Abstract Recent years have seen a flurry of research on yield stress fluids, approached from different perspectives (physicochemical, rheological and fluid mechanical), considering different length scales and timescales, using a range of tools: experimental, computational and analytical.
I. Frigaard
openaire +2 more sources
Journal of Non-Newtonian Fluid Mechanics, 2018
Abstract Yield stress materials are known to possess a certain threshold property, a strength , that must be overcome in order for flow to occur. This strength is commonly conceived as a scalar representation of the stress tensor at the yielding point, here called the yield stress tensor .
Roney L. Thompson +2 more
openaire +2 more sources
Abstract Yield stress materials are known to possess a certain threshold property, a strength , that must be overcome in order for flow to occur. This strength is commonly conceived as a scalar representation of the stress tensor at the yielding point, here called the yield stress tensor .
Roney L. Thompson +2 more
openaire +2 more sources
Rheologica Acta, 1985
New experimental data obtained from constant stress rheometers are used to show that the yield stress concept is an idealization, and that, given accurate measurements, no yield stress exists. The simple Cross model is shown to be a useful empiricism for many non-Newtonian fluids, including those which have hitherto been thought to possess a yield ...
H. A. Barnes, K. Walters
openaire +3 more sources
New experimental data obtained from constant stress rheometers are used to show that the yield stress concept is an idealization, and that, given accurate measurements, no yield stress exists. The simple Cross model is shown to be a useful empiricism for many non-Newtonian fluids, including those which have hitherto been thought to possess a yield ...
H. A. Barnes, K. Walters
openaire +3 more sources