Results 131 to 140 of about 90,068,201 (300)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Changing Debt Maturity Structure of U.S. Farms [PDF]
The objectives of this paper are to examine the debt maturity structure of farm businesses and to investigate the determinants of the farm businesses’ choice of the maturity structure.
Harris, James Michael +1 more
core
Higher capability maturity dynamics of UK construction organisations [PDF]
This paper attempts to identify the dynamics of the CMM (Capability Maturity Model) higher capability maturity level characteristics within the UK construction context from a theoretical perspective.
Amaratunga, Dilanthi +2 more
core +2 more sources
International Journal of Bio-Resource and Stress ManagementThe current study was conducted during June to October, 2019 cropping season at Asasa, Ethiopia to evaluate forty-nine field pea genotypes were evaluated in simple lattice design to assess genetic variability for morpho-agronomic traits. The analysis of
Temesgen Abo, Wassu Mohamed
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The Czech Treasury Yield Curve from 1999 to the Present [PDF]
The author estimates the Czech Treasury yield curve at a daily frequency from 1999 to the present. He uses the parsimonious yield curve model of Nelson and Siegel (1987), for which he suggests a parameter restriction that avoids abrupt changes in ...
Kamil Kladívko
core
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source