Results 131 to 140 of about 413,589 (302)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Czech Treasury Yield Curve from 1999 to the Present [PDF]

The author estimates the Czech Treasury yield curve at a daily frequency from 1999 to the present. He uses the parsimonious yield curve model of Nelson and Siegel (1987), for which he suggests a parameter restriction that avoids abrupt changes in ...
Kamil Kladívko
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic Variability Studies in Field Pea (Pisum sativum L.) for Yield and Associated Characters Evaluated at Asasa South-East Highlands of Ethiopia

International Journal of Bio-Resource and Stress Management
The current study was conducted during June to October, 2019 cropping season at Asasa, Ethiopia to evaluate forty-nine field pea genotypes were evaluated in simple lattice design to assess genetic variability for morpho-agronomic traits. The analysis of
Temesgen Abo, Wassu Mohamed
doaj   +1 more source

Cocksfoot (Dactylis glomerata L.) seed production : a thesis presented in partial fulfilment of the requirements for the degree of Master of Agricultural Science at Massey University [PDF]

, 1996
Seed yield reduction due to variation in genotype, management, and incidence of diseases is common and well documented in grass seed crops. Two New Zealand cultivars (Grasslands Wana, Grasslands Kara) and two Japanese (Akimidori Makibamidori) cocksfoot ...
Zahid, Md Iqbal
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A Reduced Form Model of Default Spreads with Markov Switching Macroeconomic Factors [PDF]

An important research area of the corporate yield spread literature seeks to measure the proportion of the spread explained by factors such as the possibility of default, liquidity or tax differentials.
Geneviève Gauthier, Georges Dionne, Jean-Guy Simonato, Khemais Hammami, Mathieu Maurice   +4 more
core  

Genetic Variability and Relative Importance of Nine Phenological and Physiological Characters Studied in Spring Wheat (Triticum aestivum L.) [PDF]

, 2015
Experiment was designed to establish a more definitive relationship of phenological and physiological traits with yield in wheat using twenty five spring wheat genotypes.
Abul Awlad Khan
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source